Sfpq Gene Summary [Mouse]
Enables chromatin binding activity and transcription cis-regulatory region binding activity. Involved in several processes, including dendritic transport of messenger ribonucleoprotein complex; negative regulation of DNA-templated transcription; and negative regulation of circadian rhythm. Acts upstream of or within DNA damage response; chromosome organization; and positive regulation of sister chromatid cohesion. Located in paraspeckles. Part of RNA polymerase II transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; lung mesenchyme; sensory organ; and testis. Orthologous to human SFPQ (splicing factor proline and glutamine rich). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sfpq |
| Official Name | splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) [Source:MGI Symbol;Acc:MGI:1918764] |
| Ensembl ID | ENSMUSG00000028820 |
| Bio databases IDs | |
| Aliases | splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) |
| Synonyms | 1110004P21RIK, 2810416M14Rik, 5730453G22RIK, 9030402K04Rik, D4Ertd314e, Gm12940, LOC100504686, LOC100506168, LOC252855, Myoblast Antigen 24.1D5, POMP100, PPP1R140, PSF, Ptb associated splicing factor, REP1, splicing factor proline and glutamine rich, splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sfpq often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RNA recognition motif (RRM) superfamily
- NOPS (NUC059) domain
- DNA binding domain
- RNA recognition motif
- nucleic acid binding
- histone deacetylase binding
- chromatin binding
- protein binding
- sequence-specific DNA binding
- DNA binding
- eNOPS_SF
- double-stranded DNA binding
- protein homodimerization
- RNA-binding domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- tumorigenesis
- major depression
role in cell
- proliferation
- apoptosis
- expression in
- activation in
- differentiation
- remodeling
- replication in
- transcription in
- cell cycle progression
- alternative splicing in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- detergent resistant lipid raft fraction
- interchromatin granule-associated zone
- Cytoplasm
- Mitochondria
- cytosol
- nuclear pores
- nucleoplasm
- nucleoli
- nuclear bodies
- nuclear rim
- interchromatin granule clusters
- nuclear speckles
- nuclear matrix
- extranucleolar nucleoplasm
- chromatin
- detergent-soluble fraction
- paraspeckle-like structures
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sfpq gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- double-strand break repair via homologous recombination
- regulation of transcription, DNA-dependent
- mRNA processing
- regulation of circadian rhythm
- positive regulation of transcription from RNA polymerase II promoter
- negative regulation of circadian rhythm
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- rhythmic process
- negative regulation of transcription, DNA-dependent
- activation of innate immune response
- innate immune response
- alternative nuclear mRNA splicing, via spliceosome
Cellular Component
Where in the cell the gene product is active
- nucleus
- paraspeckles
- nuclear speck
- cytosol
- nuclear matrix
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- protein homodimerization activity
- RNA binding
- histone deacetylase binding
- transcription regulatory region sequence-specific DNA binding
- chromatin binding