Pcdh15 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity. Acts upstream of or within several processes, including adult walking behavior; detection of mechanical stimulus involved in sensory perception; and plasma membrane bounded cell projection organization. Located in cytoplasm; photoreceptor outer segment; and plasma membrane. Is active in stereocilium. Is expressed in several structures, including central nervous system; gut epithelium; metanephros; sensory organ; and vibrissa follicle. Used to study Usher syndrome type 1F and autosomal recessive nonsyndromic deafness 23. Human ortholog(s) of this gene implicated in Usher syndrome type 1D; Usher syndrome type 1F; and autosomal recessive nonsyndromic deafness 23. Orthologous to human PCDH15 (protocadherin related 15). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Pcdh15 |
| Official Name | protocadherin 15 [Source:MGI Symbol;Acc:MGI:1891428] |
| Ensembl ID | ENSMUSG00000052613 |
| Bio databases IDs | |
| Aliases | protocadherin 15 |
| Synonyms | av, BB078305, CDHR15, DFNB23, Gm9815, LOC100910991, LOC687745, NEWGENE 1590969, nmf19, Protocadherin 15, protocadherin related 15, roda, USH1F |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pcdh15 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Pcdh15a common domain
- cytoplasmic domain
- transmembrane domain
- Cadherin repeat-like domain
- protein binding
- calcium binding loop
- Extracellular Cadherin domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Usher syndrome type 1F
- autosomal recessive deafness type 23
- irritable bowel syndrome
- Usher syndrome type 1D
- Usher syndrome type 1
- schizophrenia
- familial nonsyndromic hearing impairment
- osteoporosis
- retinal dystrophy
- Usher syndrome
regulates
- stretch activated ion channel
role in cell
- differentiation
- migration
- cell death
- number
- maintenance
- assembly
- organization
- morphology
- opening in
- scattering
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- type I auditory nerve fiber
- cochlear hair cell stereocilia
- Cytoplasm
- cell surface
- Extracellular Space
- apical compartment
- basal compartment
- perinuclear region
- cellular membrane
- vesicles
- stereocilia
- apical cell surfaces
- basolateral membrane
- nerve ending
- synapse
- photoreceptor outer segments
- cuticular plate
- filopodial tip
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pcdh15 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sensory perception of sound
- inner ear development
- photoreceptor cell maintenance
- equilibrioception
- cell adhesion
- homophilic cell adhesion
- sensory perception of light stimulus
Cellular Component
Where in the cell the gene product is active
- synapse
- stereocilium
- extracellular region
- plasma membrane
- photoreceptor outer segment
Molecular Function
What the gene product does at the molecular level
- calcium ion binding