Myo7a Gene Summary [Mouse]
Enables protein domain specific binding activity. Involved in protein localization. Acts upstream of or within several processes, including inner ear development; phagolysosome assembly; and pigment granule transport. Located in several cellular components, including melanosome; photoreceptor connecting cilium; and stereocilium base. Is active in stereocilium. Is expressed in central nervous system; liver; sensory organ; and small intestine epithelium. Used to study Usher syndrome type 1 and autosomal recessive nonsyndromic deafness 2. Human ortholog(s) of this gene implicated in Leber congenital amaurosis; Usher syndrome (multiple); auditory system disease (multiple); and congenital nystagmus. Orthologous to human MYO7A (myosin VIIA). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Myo7a |
| Official Name | myosin VIIA [Source:MGI Symbol;Acc:MGI:104510] |
| Ensembl ID | ENSMUSG00000030761 |
| Bio databases IDs | |
| Aliases | myosin VIIA |
| Synonyms | DFNA11, DFNB2, Hdb, Myo7, myosin VIIA, MYOVIIA, MYU7A, nmf371, NSRD2, polka, sh-1, USH1B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Myo7a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Arginine and glutamate-rich 1
- UDM1_RNF168_RNF169-like
- ADP binding
- ATP binding
- rRNA-processing protein Efg1
- microfilament motor protein
- spectrin binding
- coiled-coil domain
- enzyme
- motor domain
- identical protein binding
- MyTH4 domain
- FERM domain
- Vacuolar (H+)-ATPase G subunit
- Calmodulin-binding motif
- Coiled-coil domain-containing protein 50 N-terminus
- actin binding
- IQ domain
- tail domain
- FERM domain B-lobe
- FERM central domain
- Band 4.1 homologues
- calmodulin binding
- PspA/IM30 family
- Myosin and Kinesin motor domain
- protein domain specific binding
- protein binding
- Pleckstrin homology-like domain
- Myosin head (motor domain)
- Src Homology 3 domain superfamily
- IQ calmodulin-binding motif
- actin filament binding
- binding protein
- Ubl1_cv_Nsp3_N-like
- motor protein
- Myosin
- Coiled-coil domain-containing protein 66
Pathways
Biological processes and signaling networks where the Myo7a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive deafness type 2
- ear malformation
- Usher syndrome type 1B
- Usher syndrome type 1
- Usher syndrome
- retinal dystrophy
- autosomal dominant 11 deafness
- Usher syndrome type 2
- autosomal recessive deafness
- hereditary disorder
phenotypes
- abnormal behavior
- abnormal bone mineralization
- abnormal locomotor activation
- absent pinna reflex
- decreased body weight
- decreased circulating glucose level
- impaired righting response
- increased blood urea nitrogen level
- increased circulating calcium level
- increased circulating sodium level
- increased lean body mass
- increased thermal nociceptive threshold
- increased total body fat amount
- persistence of hyaloid vascular system
- stereotypic behavior
- trunk curl
- abnormal auditory summating potential
- abnormal cochlear OHC efferent innervation pattern
- abnormal cochlear basement membrane morphology
- abnormal cochlear hair cell inter-stereocilial links morphology
- abnormal cochlear hair cell morphology
- abnormal cochlear hair cell stereociliary bundle morphology
- abnormal cochlear nerve compound action potential
- abnormal cochlear outer hair cell morphology
- abnormal ear physiology
- abnormal electroretinogram waveform feature
- abnormal gait
- abnormal hair cell morphology
- abnormal head movements
- abnormal hearing physiology
- abnormal inner ear vestibule morphology
- abnormal inner hair cell stereociliary bundle morphology
- abnormal organ of Corti morphology
- abnormal orientation of cochlear hair cell stereociliary bundles
- abnormal orientation of inner hair cell stereociliary bundles
- abnormal orientation of outer hair cell stereociliary bundles
- abnormal outer hair cell stereociliary bundle morphology
- abnormal parental behavior
- abnormal retinal pigment epithelium morphology
- abnormal retinal rod cell morphology
- abnormal vestibular hair cell stereociliary bundle morphology
- absent cochlear hair bundle ankle links
- absent cochlear microphonics
- absent distortion product otoacoustic emissions
- absent linear vestibular evoked potential
- absent startle reflex
- circling
- cochlear degeneration
- cochlear ganglion degeneration
- cochlear hair cell degeneration
- cochlear outer hair cell degeneration
- deafness
- decreased a wave amplitude
- decreased b wave amplitude
- decreased body size
- decreased cochlear outer hair cell number
- decreased inner hair cell stereocilia number
- decreased outer hair cell stereocilia number
- decreased startle reflex
- decreased vestibular hair cell stereocilia number
- fused inner hair cell stereocilia
- gliosis
- head bobbing
- head shaking
- head tilt
- head tossing
- hyperactivity
- impaired balance
- impaired hearing
- impaired pupillary reflex
- impaired swimming
- increased anxiety-related response
- increased cochlear nerve compound action potential
- increased fluid intake
- increased food intake
- increased or absent threshold for auditory brainstem response
- increased susceptibility to age-related hearing loss
- jerky movement
- male infertility
- reduced male fertility
- retinal rod cell degeneration
- retropulsion
- sensorineural hearing loss
- short cochlear hair cell stereocilia
- short cochlear outer hair cells
- slow postnatal weight gain
- spinning
- straub tail
- stria vascularis degeneration
- thin stria vascularis
- vestibular ganglion hypoplasia
- vestibular saccular macula degeneration
role in cell
- accumulation
- accumulation in
- phagocytosis by
- survival
- quantity
- differentiation
- degeneration
- depolarization
- aggregation
- organization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- kinocilia
- cilia
- apical compartment
- membrane surface
- vesicles
- lysosome
- cytosol
- connecting cilia
- stereocilia
- lateral cell surfaces
- apical membrane
- plasma membrane projections
- lysosome membrane
- nerve ending
- synapse
- photoreceptor outer segments
- photoreceptor inner segments
- cuticular plate
- melanosomes
- anchoring junction
- microvilli
- perikaryon
- exosomes
- cell-cell adherens junctions
- apical processes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Myo7a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- auditory receptor cell stereocilium organization
- lysosome organization
- cochlea development
- protein localization
- eye photoreceptor cell development
- actin filament organization
- visual perception
- endocytosis
- intracellular protein transport
- sensory organ development
- sensory perception of sound
- mechanoreceptor differentiation
- phagolysosome assembly
- equilibrioception
- pigment granule transport
- actin filament-based movement
- sensory perception of light stimulus
Cellular Component
Where in the cell the gene product is active
- photoreceptor connecting cilium
- synapse
- lysosomal membrane
- photoreceptor outer segment
- cytoplasm
- microvillus
- melanosome
- cell cortex
- membrane
- actin cytoskeleton
- cytosol
- stereocilium
- photoreceptor inner segment
- myosin VII complex
- apical plasma membrane
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATP binding
- protein domain specific binding
- identical protein binding
- calmodulin binding
- protein binding
- spectrin binding
- ADP binding
- microfilament motor activity