Adgrv1 Gene Summary [Mouse]
Enables several functions, including G-protein alpha-subunit binding activity; adenylate cyclase inhibitor activity; and myosin binding activity. Involved in several processes, including negative regulation of adenylate cyclase activity; positive regulation of bone mineralization; and self proteolysis. Acts upstream of or within several processes, including detection of mechanical stimulus involved in sensory perception of sound; inner ear receptor cell stereocilium organization; and positive regulation of cAMP/PKA signal transduction. Located in several cellular components, including periciliary membrane compartment; photoreceptor connecting cilium; and stereocilia ankle link. Part of USH2 complex and stereocilia ankle link complex. Is active in stereocilium. Is expressed in several structures, including brain; eye; neural ectoderm; reproductive system; and spinal cord. Used to study Usher syndrome type 2C. Human ortholog(s) of this gene implicated in Usher syndrome type 2C and familial febrile seizures 4. Orthologous to human ADGRV1 (adhesion G protein-coupled receptor V1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Adgrv1 |
| Official Name | adhesion G protein-coupled receptor V1 [Source:MGI Symbol;Acc:MGI:1274784] |
| Ensembl ID | ENSMUSG00000069170 |
| Bio databases IDs | |
| Aliases | adhesion G protein-coupled receptor V1 |
| Synonyms | adhesion G protein-coupled receptor V1, FEB4, Frings, GPR98, LOC362068, MASS1, Mgr1, RGD1562101, USH2B, USH2C, VLGR1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Adgrv1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 7 transmembrane receptor (Secretin family)
- LamG
- enzyme inhibitor activity
- calcium ion binding
- enzyme regulator activity
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- EPTP domain
- Domains in Na-Ca exchangers and integrin-beta4
- myosin binding
- Concanavalin A-like lectin/glucanases superfamily
- cytoplasmic domain
- GPCR proteolysis site, GPS, motif
- cytosolic tail domain
- Calx-beta domain
- PDZ binding motif
Pathways
Biological processes and signaling networks where the Adgrv1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- chronic obstructive pulmonary disease
- cutaneous melanoma
- Usher syndrome
- opioid dependence
- retinal dystrophy
- type IIC Usher syndrome
- idiopathic generalized epilepsy
- atopy
- autosomal recessive sensorineural hearing loss
role in cell
- organization
- mechanotransduction
- degeneration
- function
- response by
- entrance by
- lack
- abnormal morphology
- orientation
- disorganization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- type I auditory nerve fiber
- cochlear hair cell stereocilia
- Cytoplasm
- cilia
- cell surface
- apical compartment
- basal compartment
- perinuclear region
- cellular membrane
- vesicles
- connecting cilia
- stereocilia
- basolateral membrane
- nerve ending
- filopodial tip
- perikaryon
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Adgrv1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inner ear receptor stereocilium organization
- negative regulation of adenylate cyclase activity
- inner ear receptor cell differentiation
- inner ear development
- G-protein coupled receptor signaling pathway
- positive regulation of protein kinase C signaling cascade
- nervous system development
- cell surface receptor signaling pathway
- visual perception
- establishment of protein localization
- maintenance of organ identity
- sensory perception of sound
- positive regulation of protein kinase A signaling cascade
- self proteolysis
- regulation of protein stability
- cellular response to calcium ion
- photoreceptor cell maintenance
- sensory perception of light stimulus
- detection of mechanical stimulus involved in sensory perception of sound
- neurological system process
- positive regulation of bone mineralization
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- membrane
- stereocilia ankle link
- receptor complex
- stereocilia ankle link complex
- stereocilium
- stereocilium membrane
- photoreceptor inner segment
- plasma membrane
- cell surface
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- protein binding
- G-protein alpha-subunit binding
- calcium ion binding
- adenylate cyclase inhibitor activity
- hydrolase activity