Spink2 Gene Summary [Mouse]
Predicted to enable serine-type endopeptidase inhibitor activity. Involved in acrosome assembly. Acts upstream of or within several processes, including male germ cell proliferation; negative regulation of serine-type endopeptidase activity; and seminiferous tubule development. Located in acrosomal vesicle and neuron projection. Is expressed in intestine; male reproductive gland or organ; oviduct; skin; and tongue. Human ortholog(s) of this gene implicated in spermatogenic failure 29. Orthologous to human SPINK2 (serine peptidase inhibitor Kazal type 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spink2 |
| Official Name | serine peptidase inhibitor, Kazal type 2 [Source:MGI Symbol;Acc:MGI:1917232] |
| Ensembl ID | ENSMUSG00000053030 |
| Bio databases IDs | |
| Aliases | serine peptidase inhibitor, Kazal type 2 |
| Synonyms | 1700007F22RIK, HUSI-II, LOC100910138, serine peptidase inhibitor Kazal type 2, serine peptidase inhibitor, Kazal type 2, SPGF29 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spink2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- endopeptidase inhibitor
- protein binding
- KAZAL_FS
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- acrosome
- neurites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spink2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- acrosome assembly
- spermatid development
- negative regulation of serine-type endopeptidase activity
Cellular Component
Where in the cell the gene product is active
- acrosomal vesicle
- extracellular region
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- endopeptidase inhibitor activity
- protein binding