Atp6v1e2 Gene Summary [Mouse]
Enables proton-transporting ATPase activity, rotational mechanism. Acts upstream of or within proton transmembrane transport. Located in acrosomal vesicle. Orthologous to human ATP6V1E2 (ATPase H+ transporting V1 subunit E2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Atp6v1e2 |
| Official Name | ATPase, H+ transporting, lysosomal V1 subunit E2 [Source:MGI Symbol;Acc:MGI:1922165] |
| Ensembl ID | ENSMUSG00000053375 |
| Bio databases IDs | |
| Aliases | ATPase, H+ transporting, lysosomal V1 subunit E2 |
| Synonyms | 4930500C14Rik, ATP6E1, ATP6EL2, ATP6V1EL2, ATPase, H+ transporting, lysosomal V1 subunit E2, ATPase H+ transporting V1 subunit E2, E1, LOC102725172, LOC440862, V Atpase E1, V-ATPase E2, VMA4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Atp6v1e2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- hydrogen-transporting ATPase activity, rotational mechanism
- protein binding
- ATP synthase (E/31 kDa) subunit
- transporter
Pathways
Biological processes and signaling networks where the Atp6v1e2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- acrosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Atp6v1e2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of macroautophagy
Cellular Component
Where in the cell the gene product is active
- acrosomal vesicle
- cytosol
- proton-transporting two-sector ATPase complex, catalytic domain
Molecular Function
What the gene product does at the molecular level
- protein binding
- proton-transporting ATPase activity, rotational mechanism