Grwd1 Gene Summary [Mouse]
Predicted to enable DNA replication origin binding activity; chromatin binding activity; and histone binding activity. Predicted to be involved in DNA replication; nucleosome organization; and ribosome biogenesis. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nucleolus. Is expressed in embryo. Orthologous to human GRWD1 (glutamate rich WD repeat containing 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Grwd1 |
| Official Name | glutamate-rich WD repeat containing 1 [Source:MGI Symbol;Acc:MGI:2141989] |
| Ensembl ID | ENSMUSG00000053801 |
| Bio databases IDs | |
| Aliases | glutamate-rich WD repeat containing 1 |
| Synonyms | A301, CDW4, glutamate-rich WD repeat containing 1, GRWD, RRB1, WDR28 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Grwd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 4 WD40 domain
- Histone-binding protein RBBP4 or subunit C of CAF1 complex
- histone binding
- WD40 repeats
- DNA replication origin binding
- WD domain, G-beta repeat
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Grwd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA replication
- ribosome biogenesis
- nucleosome disassembly
- nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- macromolecular complex
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA replication origin binding
- RNA binding
- protein binding
- histone binding
- chromatin binding