Cdc6 Gene Summary [Mouse]
Enables chromatin binding activity. Predicted to be involved in DNA replication initiation; positive regulation of fibroblast proliferation; and regulation of cell cycle process. Located in cytoplasm and spindle. Is expressed in central nervous system; heart; and retina. Human ortholog(s) of this gene implicated in Meier-Gorlin syndrome 5. Orthologous to human CDC6 (cell division cycle 6). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cdc6 |
| Official Name | cell division cycle 6 [Source:MGI Symbol;Acc:MGI:1345150] |
| Ensembl ID | ENSMUSG00000017499 |
| Bio databases IDs | |
| Aliases | cell division cycle 6 |
| Synonyms | CDC18L, Cdc6-related, cell division cycle 6, HsCDC18, HsCDC6, MGORS5, p62(cdc6) |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cdc6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleotide binding
- AAA ATPase domain
- protein kinase binding
- walker type B motif
- orc1/cdc6 family replication initiation protein
- walker type A motif
- chromatin binding
- cyclin recognition motif
- protein binding
- phosphorylation site
- AAA domain
- ATPase family associated with various cellular activities (AAA)
- kinase binding
- ATPase domain
- Caspase 3 cleavage site
- N-terminal helicase domain of the DEAD-box helicase superfamily
- DEAD-like helicases superfamily
- Cdc6 winged-helix domain
- CDC6, C terminal winged helix domain
- P-loop containing Nucleoside Triphosphate Hydrolases
- ATPases associated with a variety of cellular activities
Pathways
Biological processes and signaling networks where the Cdc6 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- small cell lung cancer
- neoplasia
- epithelial neoplasia
- epithelial cancer
- cancer
- prostatic adenocarcinoma
- prostate cancer
- lung adenocarcinoma
- lung adenocarcinoma formation
- hepatocellular carcinoma
role in cell
- quantity
- binding
- proliferation
- binding in
- expression in
- damage in
- cell death
- growth
- apoptosis
- migration
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- chromatin fraction
- spindle apparatus
- Cytoplasm
- cytoplasmic bridges
- cytosol
- nucleoplasm
- spindle pole
- central spindle
- mitotic spindle
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cdc6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA-dependent DNA replication initiation
- regulation of mitotic metaphase/anaphase transition
- negative regulation of cell proliferation
- traversing start control point of mitotic cell cycle
- negative regulation of DNA replication
- regulation of cyclin-dependent protein kinase activity
- cell division
- positive regulation of chromosome segregation
- DNA replication checkpoint
- positive regulation of fibroblast proliferation
- positive regulation of cytokinesis
- mitotic cell cycle DNA replication checkpoint
Cellular Component
Where in the cell the gene product is active
- nucleus
- intercellular bridge
- spindle midzone
- mitotic spindle
- cytoplasm
- spindle pole
- cytosol
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- nucleotide binding
- ATPase activity
- DNA replication origin binding
- ATP binding
- protein binding
- kinase binding