GRWD1 Gene Summary [Human]
This gene encodes a glutamate-rich protein that contains five WD-repeat motifs. The encoded protein may play a critical role in ribosome biogenesis and may also play a role in histone methylation through interactions with CUL4-DDB1 ubiquitin E3 ligase. [provided by RefSeq, Feb 2012]
Details
| Type | Protein Coding |
| Official Symbol | GRWD1 |
| Official Name | glutamate rich WD repeat containing 1 [Source:HGNC Symbol;Acc:HGNC:21270] |
| Ensembl ID | ENSG00000105447 |
| Bio databases IDs | |
| Aliases | glutamate rich WD repeat containing 1 |
| Synonyms | A301, CDW4, glutamate-rich WD repeat containing 1, GRWD, RRB1, WDR28 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GRWD1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Anaphase-promoting complex subunit 4 WD40 domain
- Histone-binding protein RBBP4 or subunit C of CAF1 complex
- histone binding
- WD40 repeats
- DNA replication origin binding
- WD domain, G-beta repeat
- chromatin binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- cytosol
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GRWD1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- DNA replication
- ribosome biogenesis
- nucleosome disassembly
- nucleosome assembly
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytosol
- macromolecular complex
- chromosome
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA replication origin binding
- RNA binding
- protein binding
- histone binding
- chromatin binding