Sirt5 Gene Summary [Mouse]
Enables protein-glutaryllysine deglutarylase activity; protein-malonyllysine demalonylase activity; and protein-succinyllysine desuccinylase activity. Involved in protein deacylation and regulation of ketone biosynthetic process. Acts upstream of or within regulation of succinate dehydrogenase activity and response to ischemia. Located in cytosol and mitochondrial inner membrane. Is expressed in several structures, including 1st branchial arch maxillary component; oocyte; palatal shelf; sensory organ; and tibialis anterior. Orthologous to human SIRT5 (sirtuin 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Sirt5 |
| Official Name | sirtuin 5 [Source:MGI Symbol;Acc:MGI:1915596] |
| Ensembl ID | ENSMUSG00000054021 |
| Bio databases IDs | |
| Aliases | sirtuin 5 |
| Synonyms | 0610012J09RIK, 1500032M05RIK, LOC285813, SIR2L5, sirtuin 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sirt5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NAD or NADH binding
- binding protein
- zinc ion binding
- linear amide carbon-nitrogen bond hydrolase
- enzyme
- protein binding
- SIR2
- Non-amino-acyl group acyltransferase
Pathways
Biological processes and signaling networks where the Sirt5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- liver cancer
- epithelial cancer
- myocardial necrosis
- prostate cancer
- tumorigenesis
- organismal death
- hypertrophic cardiomyopathy
- hepatocellular carcinoma
- mitochondrial disorder
role in cell
- growth
- apoptosis
- phosphorylation in
- expression in
- production in
- proliferation
- migration
- degradation in
- invasion by
- survival
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Mitochondria
- cytosol
- mitochondrial matrix
- mitochondrial intermembrane space
- mitochondrial inner membrane
- peroxisomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sirt5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein demalonylation
- peptidyl-lysine demalonylation
- protein desuccinylation
- regulation of ketone biosynthetic process
- protein deacetylation
- negative regulation of cardiac muscle cell apoptotic process
- peptidyl-lysine desuccinylation
- response to nutrient levels
- regulation of gene expression, epigenetic
- mitochondrion organization
- negative regulation of reactive oxygen species metabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- mitochondrial intermembrane space
- mitochondrial matrix
- mitochondrion
- cytosol
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- NAD-dependent protein deacetylase activity
- protein-malonyllysine demalonylase activity
- protein-succinyllysine desuccinylase activity
- NAD+ binding
- NAD+ ADP-ribosyltransferase activity