Iigp1 Gene Summary [Mouse]
Enables GTPase activity; guanyl ribonucleotide binding activity; and identical protein binding activity. Involved in defense response to Gram-negative bacterium; defense response to protozoan; and regulation of autophagy. Acts upstream of or within cellular response to interferon-beta and response to bacterium. Located in endoplasmic reticulum membrane and symbiont-containing vacuole membrane. Is active in cytoplasm. Is expressed in several structures, including foregut; genitourinary system; heart; limb; and respiratory system. [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Iigp1 |
| Official Name | interferon inducible GTPase 1 [Source:MGI Symbol;Acc:MGI:1926259] |
| Ensembl ID | ENSMUSG00000054072 |
| Bio databases IDs | |
| Aliases | interferon inducible GTPase 1 |
| Synonyms | 2900074L10Rik, Ifgga1, Iigp, Interferon-inducible GTPase, interferon inducible GTPase 1, Irga6 |
| Species | Mouse, Mus musculus |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Iigp1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GTP binding
- GDP binding
- 50S ribosome-binding GTPase
- GTPase
- Interferon-inducible GTPase (IIGP)
- enzyme
- protein binding
- identical protein binding
- P-loop containing Nucleoside Triphosphate Hydrolases
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- guanosine triphosphate
- GDP
- guanosine 5'-O-(3-thiotriphosphate)
disease
- Huntington disease
- dextran sodium sulfate-induced colitis
- insulin-dependent diabetes mellitus
- infection by parasite
regulates
- guanosine triphosphate
- GDP
role in cell
- autophagy by
- replication
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- parasitophorous vacuole
- Cytoplasm
- endoplasmic reticulum membrane