Tyk2 Gene Summary [Mouse]
Predicted to enable growth hormone receptor binding activity; non-membrane spanning protein tyrosine kinase activity; and type 1 angiotensin receptor binding activity. Involved in cell population proliferation and positive regulation of T cell proliferation. Predicted to be located in cytoplasm and nucleus. Predicted to be part of interleukin-12 receptor complex and interleukin-23 receptor complex. Predicted to be active in cytosol. Used to study obesity. Human ortholog(s) of this gene implicated in immunodeficiency 35. Orthologous to human TYK2 (tyrosine kinase 2). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Retained Intron |
| Official Symbol | Tyk2 |
| Official Name | tyrosine kinase 2 [Source:MGI Symbol;Acc:MGI:1929470] |
| Ensembl ID | ENSMUSG00000032175 |
| Bio databases IDs | |
| Aliases | tyrosine kinase 2 |
| Synonyms | IMD35, JTK1, tyrosine kinase 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Tyk2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Jak Homology domain
- G-protein-coupled receptor binding
- protein-tyrosine kinase
- Protein kinase domain
- FERM domain
- Src homology 2 (SH2) domain
- FERM domain B-lobe
- Tyrosine kinase, catalytic domain
- Band 4.1 homologues
- Protein kinase (unclassified specificity)
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- kinase-like domain
- nuclear localization sequence
- non-membrane spanning protein tyrosine kinase
- FERM F1 ubiquitin-like domain
- protein binding
- Pleckstrin homology-like domain
- pseudo kinase domain
- kinase
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Ubl1_cv_Nsp3_N-like
- Jak1 pleckstrin homology-like domain
- tyrosine kinase domain
- active site
- growth hormone receptor binding
Pathways
Biological processes and signaling networks where the Tyk2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
- CNTF Signaling
- ErbB2-ErbB3 Signaling
- Glucocorticoid Receptor Signaling
- IL-15 Production
- IL-17A Signaling in Airway Cells
- IL-22 Signaling
- iNOS Signaling
- Interferon Signaling
- JAK/Stat Signaling
- Oncostatin M Signaling
- Pancreatic Adenocarcinoma Signaling
- Regulation of the Epithelial-Mesenchymal Transition Pathway
- Role of Hypercytokinemia/hyperchemokinemia in the Pathogenesis of Influenza
- Role of JAK1, JAK2 and TYK2 in Interferon Signaling
- Role of JAK2 in Hormone-like Cytokine Signaling
- Role of NANOG in Mammalian Embryonic Stem Cell Pluripotency
- Role of PKR in Interferon Induction and Antiviral Response
- SPINK1 General Cancer Pathway
- STAT3 Pathway
- Th1 Pathway
- Th17 Activation Pathway
- Th2 Pathway
- Transcriptional Regulatory Network in Embryonic Stem Cells
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- rheumatoid arthritis
- systemic lupus erythematosus
- plaque psoriasis
- COVID-19
- acute myeloid leukemia
- multiple sclerosis
- atopic dermatitis
- ulcerative colitis
- juvenile psoriatic arthritis
- psoriasis
role in cell
- quantity
- cellular infiltration by
- expression in
- phosphorylation in
- activation in
- proliferation
- response
- cell death
- formation
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- intracellular space
- focal adhesions
- Nucleus
- Plasma Membrane
- cytosol
- cell membrane leading edge
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Tyk2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of protein localization to nucleus
- JAK-STAT cascade involved in growth hormone signaling pathway
- interferon-gamma-mediated signaling pathway
- positive regulation of T cell proliferation
- protein phosphorylation
- type I interferon-mediated signaling pathway
- JAK-STAT cascade
- positive regulation of JAK-STAT cascade
- positive regulation of T-helper 17 type immune response
- immune response
- positive regulation of natural killer cell proliferation
- cytokine-mediated signaling pathway
- positive regulation of interferon-gamma production
- positive regulation of NK T cell proliferation
- cell differentiation
- positive regulation of interleukin-17 production
- intracellular signal transduction
- interleukin-12-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- extracellular vesicular exosome
- cytoplasm
- interleukin-23 receptor complex
- interleukin-12 receptor complex
- extrinsic to internal side of plasma membrane
- cytosol
- extrinsic to plasma membrane
- plasma membrane
- internal side of plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- protein tyrosine kinase activity
- type 1 angiotensin receptor binding
- protein binding
- non-membrane spanning protein tyrosine kinase activity
- growth hormone receptor binding