Lclat1 Gene Summary [Mouse]
Enables acyltransferase activity. Predicted to be involved in phosphatidylinositol acyl-chain remodeling. Located in endoplasmic reticulum. Is expressed in several structures, including gut; heart; immune system; ovary; and respiratory system. Orthologous to human LCLAT1 (lysocardiolipin acyltransferase 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lclat1 |
| Official Name | lysocardiolipin acyltransferase 1 [Source:MGI Symbol;Acc:MGI:2684937] |
| Ensembl ID | ENSMUSG00000054469 |
| Bio databases IDs | |
| Aliases | lysocardiolipin acyltransferase 1 |
| Synonyms | 1-AGPAT 8, AGPAT8, ALCAT1, Gm91, HSRG1849, LPLAT6, LYCAT, lysocardiolipin acyltransferase 1, Mlcl at, RGD1565906, UNQ1849 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lclat1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
- 1-acylglycerol-3-phosphate O-acyltransferase
- enzyme
- protein binding
- Acyltransferase
- Acyltransferase C-terminus
- transferase, transferring acyl groups
- O-acyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- obesity
- polydipsia
- eczema
- diabetic nephropathy
- hyperactive behavior
- hyperphagia
regulated by
- arachidonyl-coenzyme A
- linoleoyl-coenzyme A
- stearoyl-coenzyme A
- oleoyl-coenzyme A
- palmitoyl-coenzyme A
- HES3
role in cell
- fusion
- production in
- expression in
- fragmentation
- depletion in
- dysfunction
- fragmentation in
- damage
- damage in
- size
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- cytosol
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lclat1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cardiolipin acyl-chain remodeling
- CDP-diacylglycerol biosynthetic process
- phosphatidylinositol acyl-chain remodeling
- phosphatidic acid biosynthetic process
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- cytosol
- endomembrane system
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- 1-acylglycerol-3-phosphate O-acyltransferase activity
- transferase activity, transferring acyl groups
- protein binding
- O-acyltransferase activity