Gdi2 Gene Summary [Mouse]
Contributes to GTPase activator activity. Acts upstream of or within small GTPase-mediated signal transduction. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human GDI2 (GDP dissociation inhibitor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Gdi2 |
| Official Name | guanosine diphosphate (GDP) dissociation inhibitor 2 [Source:MGI Symbol;Acc:MGI:99845] |
| Ensembl ID | ENSMUSG00000021218 |
| Bio databases IDs | |
| Aliases | guanosine diphosphate (GDP) dissociation inhibitor 2 |
| Synonyms | GDI3, GDI-B, GDP dissociation inhibitor 2, HEL-S-46e, Rab Gd1 Beta, Rab Gd1 β, RABGDIB, Rab-gdi-β, RAB GDP-DISSOCIATION |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Gdi2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Rossmann-fold NAD(P)(+)-binding proteins
- RAB GDP-dissociation inhibitor
- enzyme binding
- GTPase activator
- protein binding
- GDP dissociation inhibitor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- epithelial cancer
- prostatic carcinoma
- prostate cancer
- ischemic stroke
role in cell
- assembly
- association
- association in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- myelin enriched fraction
- secretory granule lumen
- azurophil granule lumen
- cell surface
- Extracellular Space
- cellular membrane
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- cytosol
- synapse
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Gdi2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- vesicle-mediated transport
- small GTPase mediated signal transduction
- signal transduction
- protein transport
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- focal adhesion
- cytoplasm
- membrane
- cytosol
- vesicle
- Golgi apparatus
- secretory granule lumen
- synapse
- extracellular region
- azurophil granule lumen
Molecular Function
What the gene product does at the molecular level
- Rab GDP-dissociation inhibitor activity
- protein binding
- RNA binding
- GTPase activator activity
- small GTPase binding