Prdm8 Gene Summary [Mouse]
Enables chromatin binding activity; histone H3K9 methyltransferase activity; and transcription corepressor activity. Acts upstream of or within corpus callosum morphogenesis; corticospinal tract morphogenesis; and negative regulation of DNA-templated transcription. Located in nucleus. Is expressed in several structures, including central nervous system; dorsal root ganglion; lung; retina; and testis. Human ortholog(s) of this gene implicated in progressive myoclonus epilepsy 10. Orthologous to human PRDM8 (PR/SET domain 8). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Prdm8 |
| Official Name | PR domain containing 8 [Source:MGI Symbol;Acc:MGI:1924880] |
| Ensembl ID | ENSMUSG00000035456 |
| Bio databases IDs | |
| Aliases | PR domain containing 8 |
| Synonyms | 4930565F05RIK, EPM10, KMT8D, LOC100045224, PFM5, PR domain containing 8, PR/SET domain 8 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Prdm8 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- histone lysine N-methyltransferase activity (H3-K9 specific)
- zinc finger
- transcription regulator
- histone methyltransferase
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain
- SET (Su(var)3-9, Enhancer-of-zeste, Trithorax) domain superfamily
- transcription co-repressor
- SET domain
- chromatin binding
- protein binding
- C2H2-type zinc finger
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- pruritus
- progressive myoclonic epilepsy type 10
role in cell
- expression in
- targeting
- mistargeting
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Prdm8 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- oligodendrocyte development
- chromatin remodeling
- negative regulation of transcription, DNA-dependent
- corticospinal tract morphogenesis
- regulation of transcription, DNA-dependent
- corpus callosum morphogenesis
- methylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- transcription corepressor activity
- metal ion binding
- histone methyltransferase activity (H3-K9 specific)
- chromatin binding