Usp26 Gene Summary [Mouse]
Predicted to enable K48-linked deubiquitinase activity and cysteine-type deubiquitinase activity. Involved in negative regulation of proteasomal ubiquitin-dependent protein catabolic process. Predicted to be located in nucleoplasm and sperm flagellum. Predicted to be active in cytosol and nucleus. Is expressed in testis. Human ortholog(s) of this gene implicated in X-linked spermatogenic failure 6. Orthologous to human USP26 (ubiquitin specific peptidase 26). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Usp26 |
| Official Name | ubiquitin specific peptidase 26 [Source:MGI Symbol;Acc:MGI:1933247] |
| Ensembl ID | ENSMUSG00000055780 |
| Bio databases IDs | |
| Aliases | ubiquitin specific peptidase 26 |
| Synonyms | LOC105373339, LOC107983959, LOC108353303, RGD1563443, SPGFX6, ubiquitin specific peptidase 26 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Usp26 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peptidase
- N-terminal of ubiquitin carboxyl-terminal hydrolase 37
- Ubiquitin carboxyl-terminal hydrolase
- USP domain
- protein binding
- Pleckstrin homology-like domain
- Peptidase_C19
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the Usp26 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- X-linked spermatogenic failure type 6
- male infertility
- oligozoospermia
- metastasis
- idiopathic scoliosis
- infection by HIV-1
role in cell
- expression in
- proliferation
- migration
- number
- invasiveness
- polyubiquitination in
- stabilization in
- breakage in
- double-stranded DNA break repair in
- Lys29 polyubiquitination in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- sperm tail
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Usp26 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein deubiquitination
- spermatogenesis
- proteolysis
- G1/S transition of mitotic cell cycle
- regulation of androgen receptor signaling pathway
- negative regulation of proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoskeleton
- cytosol
- sperm flagellum
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-specific protease activity
- protein binding