Zfp42 Gene Summary [Mouse]
Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within cellular response to leukemia inhibitory factor; germ cell development; and in utero embryonic development. Located in cytoplasm and nucleus. Part of protein-containing complex. Is expressed in several structures, including central nervous system; early conceptus; gonad; tail; and ureter. Orthologous to human ZFP42 (ZFP42 zinc finger protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Zfp42 |
| Official Name | zinc finger protein 42 [Source:MGI Symbol;Acc:MGI:99187] |
| Ensembl ID | ENSMUSG00000051176 |
| Bio databases IDs | |
| Aliases | zinc finger protein 42 |
| Synonyms | LOC100364508, REX-1, ZFP42 zinc finger protein, Zfp971, zinc finger protein 42, ZNF754 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Zfp42 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Zinc finger, C2H2 type
- RNA polymerase II transcription regulatory region sequence-specific binding transcriptional activator activity
- transcription regulator
- nucleic acid binding
- double-stranded DNA binding
- Zinc-finger double domain
- protein binding
- sequence-specific DNA binding
Pathways
Biological processes and signaling networks where the Zfp42 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- testicular germ cell tumor
- germ cell neoplasia
- yolk sac neoplasm
- oligozoospermia
role in cell
- expression in
- number
- proliferation
- differentiation
- adipogenic potential
- abnormal morphology
- inactivation
- pluripotency
- osteogenic differentiation
- development
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Zfp42 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- meiotic cell cycle
- male gonad development
- female gonad development
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- cytoplasm
- PcG protein complex
- chromatin
Molecular Function
What the gene product does at the molecular level
- sequence-specific DNA binding transcription factor activity
- protein binding
- metal ion binding
- RNA polymerase II core promoter proximal region sequence-specific DNA binding
- sequence-specific DNA binding RNA polymerase II transcription factor activity