Ring1 Gene Summary [Mouse]
Enables chromatin binding activity and ubiquitin-protein transferase activator activity. Acts upstream of or within with a positive effect on chromatin organization. Acts upstream of or within anterior/posterior pattern specification; camera-type eye morphogenesis; and negative regulation of DNA-templated transcription. Located in nuclear body and sex chromatin. Part of PRC1 complex. Is expressed in several structures, including central nervous system; epithelium; hemolymphoid system; reproductive system; and urinary system. Orthologous to human RING1 (ring finger protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Ring1 |
| Official Name | ring finger protein 1 [Source:MGI Symbol;Acc:MGI:1101770] |
| Ensembl ID | ENSMUSG00000024325 |
| Bio databases IDs | |
| Aliases | ring finger protein 1 |
| Synonyms | RING1A, ring finger protein 1, RNF1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Ring1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- zinc finger of C3HC4-type, RING
- chromatin binding
- enzyme regulator activity
- Ring finger domain
- protein binding
- enzyme activator activity
- RAWUL domain RING finger- and WD40-associated ubiquitin-like
- RING-type zinc-finger
- Ubl1_cv_Nsp3_N-like
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- perichromatin region
- cytosol
- nuclear foci
- interchromatin space
- nucleoplasm
- nuclear bodies
- sex chromatin
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Ring1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chromatin remodeling
- camera-type eye morphogenesis
- negative regulation of transcription, DNA-dependent
- anterior/posterior pattern specification
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- PRC1 complex
- ubiquitin ligase complex
- nuclear speck
- PcG protein complex
- cytosol
- sex chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- ubiquitin-protein ligase activator activity
- metal ion binding
- chromatin binding