Pcgf2 Gene Summary [Mouse]
Enables chromatin binding activity. Acts upstream of or within several processes, including cellular response to hydrogen peroxide; chordate embryonic development; and negative regulation of transcription by RNA polymerase II. Located in nuclear body and sex chromatin. Part of PRC1 complex. Is expressed in several structures, including adipose tissue; alimentary system; central nervous system; eye; and genitourinary system. Orthologous to human PCGF2 (polycomb group ring finger 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pcgf2 |
| Official Name | polycomb group ring finger 2 [Source:MGI Symbol;Acc:MGI:99161] |
| Ensembl ID | ENSMUSG00000018537 |
| Bio databases IDs | |
| Aliases | polycomb group ring finger 2 |
| Synonyms | MEL-18, polycomb group ring finger 2, RNF110, TPFS, ZFP144, ZINC FINGER protein 144, ZNF144 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pcgf2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PEST domain
- transcription regulator
- RAWUL domain RING finger- and WD40-associated ubiquitin-like
- Ubl1_cv_Nsp3_N-like
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- chromatin binding
- Ring finger domain
- protein binding
- Zinc finger, C3HC4 type (RING finger)
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- growth failure
- global developmental delay
- hereditary disorder
- developmental disorder
- Turnpenny-Fry syndrome
- mental retardation
role in cell
- expression in
- proliferation
- migration
- differentiation
- growth
- cell cycle progression
- colony formation
- binding in
- survival
- remodeling
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nuclear bodies
- sex chromatin
- nuclear speckles
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pcgf2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- in utero embryonic development
- anterior/posterior pattern specification
- apoptotic signaling pathway
- cellular response to hydrogen peroxide
- embryonic skeletal system morphogenesis
- negative regulation of apoptotic signaling pathway
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- PRC1 complex
- PcG protein complex
- sex chromatin
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding
- metal ion binding