Fut2 Gene Summary [Mouse]
This gene is one of three genes in mouse which encode a galactoside 2-L-fucosyltransferase. These genes differ in their developmental- and tissue-specific expression. The encoded type II membrane protein is anchored in the Golgi apparatus and controls the final step in the creation of alpha (1,2) fucosylated carbhohydrates by the addition of a terminal fucose in an alpha (1,2) linkage. This enzyme is involved in the synthesis of the Lewis antigen as well as the H-antigen, a precursor of the A and B antigens of the ABH histo-blood group. The biological function of the fucosylated carbhohydrate products is thought to involve cell-adhesion and interactions with microorganisms. Disruption of this gene results in altered glycosylation of gastric mucosa and uterine epithelia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]
Details
| Type | Protein Coding |
| Official Symbol | Fut2 |
| Official Name | fucosyltransferase 2 [Source:MGI Symbol;Acc:MGI:109374] |
| Ensembl ID | ENSMUSG00000055978 |
| Bio databases IDs | |
| Aliases | fucosyltransferase 2 |
| Synonyms | Alpha 1,2-fucosyltransferase, B12QTL1, Ftc, fucosyltransferase 2, fucosyltransferase 2 (H blood group), Futb, MFUT-II, SE, Se2, SEC2, sej, α 1,2-fucosyltransferase, α Fut2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fut2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GDP-fucose protein O-fucosyltransferase and related proteins
- Glycosyl transferase family 11
- galactoside 2-alpha-L-fucosyltransferase
- cytoplasmic domain
- transmembrane domain
- fucosyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- schizophrenia
- gastric ulcer
- Crohn disease
- gallstone
- cardiovascular disorder
- metabolic syndrome X
- psoriasis
- cobalamin deficiency
- insulin-dependent diabetes mellitus
role in cell
- phosphorylation in
- expression in
- apoptosis
- activation in
- autophagy in
- degradation in
- fucosylation in
- mitochondrial cell death
- epithelial barrier function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Golgi membrane
- trans Golgi network
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fut2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- fucosylation
- protein glycosylation
- regulation of endothelial cell proliferation
- oligosaccharide biosynthetic process
- L-fucose catabolic process
- regulation of cell adhesion
- glycosphingolipid biosynthetic process
- glycolipid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- Golgi cisterna membrane
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- fucosyltransferase activity
- protein binding
- alpha-(1,2)-fucosyltransferase activity
- galactoside 2-alpha-L-fucosyltransferase activity