Fut2 Gene Summary [Rat]
Enables galactoside 2-alpha-L-fucosyltransferase activity. Involved in fucosylation. Predicted to be located in Golgi cisterna membrane. Human ortholog(s) of this gene implicated in vitamin B12 deficiency. Orthologous to human FUT2 (fucosyltransferase 2 (H blood group)). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fut2 |
| Official Name | fucosyltransferase 2 [Source:RGD Symbol;Acc:2639] |
| Ensembl ID | ENSRNOG00000021011 |
| Bio databases IDs | |
| Aliases | fucosyltransferase 2 |
| Synonyms | Alpha 1,2-fucosyltransferase, B12QTL1, Ftc, fucosyltransferase 2, fucosyltransferase 2 (H blood group), Futb, MFUT-II, SE, Se2, SEC2, sej, α 1,2-fucosyltransferase, α Fut2 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat Fut2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GDP-fucose protein O-fucosyltransferase and related proteins
- Glycosyl transferase family 11
- galactoside 2-alpha-L-fucosyltransferase
- cytoplasmic domain
- transmembrane domain
- fucosyltransferase
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hypertension
- schizophrenia
- gastric ulcer
- Crohn disease
- gallstone
- cardiovascular disorder
- metabolic syndrome X
- psoriasis
- cobalamin deficiency
- insulin-dependent diabetes mellitus
role in cell
- phosphorylation in
- expression in
- apoptosis
- activation in
- autophagy in
- degradation in
- fucosylation in
- mitochondrial cell death
- epithelial barrier function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Golgi membrane
- trans Golgi network
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat Fut2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- carbohydrate metabolic process
- fucosylation
- protein glycosylation
- regulation of endothelial cell proliferation
- oligosaccharide biosynthetic process
- L-fucose catabolic process
- regulation of cell adhesion
- glycosphingolipid biosynthetic process
- glycolipid metabolic process
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- Golgi cisterna membrane
- Golgi membrane
- Golgi apparatus
Molecular Function
What the gene product does at the molecular level
- fucosyltransferase activity
- protein binding
- alpha-(1,2)-fucosyltransferase activity
- galactoside 2-alpha-L-fucosyltransferase activity