Dram1 Gene Summary [Mouse]
Predicted to be involved in regulation of autophagy. Predicted to be located in cytoplasm. Predicted to be active in lysosome. Is expressed in several structures, including adipose tissue; genitourinary system; gut; integumental system; and respiratory system. Human ortholog(s) of this gene implicated in acute myocardial infarction. Orthologous to human DRAM1 (DNA damage regulated autophagy modulator 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | Dram1 |
| Official Name | DNA-damage regulated autophagy modulator 1 [Source:MGI Symbol;Acc:MGI:1918962] |
| Ensembl ID | ENSMUSG00000020057 |
| Bio databases IDs | |
| Aliases | DNA-damage regulated autophagy modulator 1 |
| Synonyms | 1200002N14Rik, DNA-damage regulated autophagy modulator 1, DRAM, FLJ11259 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dram1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Frag1/DRAM/Sfk1 family
- protein binding
Pathways
Biological processes and signaling networks where the Dram1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- systemic lupus erythematosus
- cerebral aneurysm
- cleft palate
- cleft lip
- Marfan syndrome
- Shigella infection
- abnormal posturing
- idiopathic scoliosis
role in cell
- cell viability
- proliferation
- survival
- quantity
- motility
- apoptosis
- permeabilization
- tethering
- disruption
- cell death
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- lysosome
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dram1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagy
- regulation of autophagy
- apoptotic process
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- lysosomal membrane
- lysosome
Molecular Function
What the gene product does at the molecular level
- protein binding