Magel2 Gene Summary [Mouse]
Predicted to enable ubiquitin-protein transferase activity. Involved in negative regulation of DNA-templated transcription and regulation of circadian rhythm. Acts upstream of or within positive regulation of actin nucleation. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; egg cylinder; limb bud; pharynx; and reproductive system. Used to study Prader-Willi syndrome. Human ortholog(s) of this gene implicated in Schaaf-Yang syndrome. Orthologous to human MAGEL2 (MAGE family member L2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Magel2 |
| Official Name | MAGE family member L2 [Source:MGI Symbol;Acc:MGI:1351648] |
| Ensembl ID | ENSMUSG00000056972 |
| Bio databases IDs | |
| Aliases | MAGE family member L2 |
| Synonyms | AC270095.1, LOC681515, MAGE family member L2, NDNL1, nM15, ns7, PWLS, SHFYNG |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Magel2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Formin Homology Region 1
- MAGE homology domain
- ubiquitin-protein transferase activity
- enzyme
- Proline-rich protein
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- endosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Magel2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- rhythmic process
- negative regulation of transcription, DNA-dependent
- Arp2/3 complex-mediated actin nucleation
- protein K63-linked ubiquitination
- regulation of circadian rhythm
- retrograde transport, endosome to Golgi
- positive regulation of actin nucleation
Cellular Component
Where in the cell the gene product is active
- nucleus
- early endosome
- endosome
- retromer complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding