Eif4a1 Gene Summary [Mouse]
Predicted to enable double-stranded RNA binding activity and translation initiation factor activity. Predicted to be involved in cytoplasmic translational initiation and positive regulation of transcription by RNA polymerase II. Predicted to be located in nuclear stress granule; perinuclear region of cytoplasm; and plasma membrane. Predicted to be part of eukaryotic translation initiation factor 4F complex. Is expressed in several structures, including central nervous system; liver; lung; ovary; and sensory organ. Orthologous to human EIF4A1 (eukaryotic translation initiation factor 4A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Eif4a1 |
| Official Name | eukaryotic translation initiation factor 4A1 [Source:MGI Symbol;Acc:MGI:95303] |
| Ensembl ID | ENSMUSG00000059796 |
| Bio databases IDs | |
| Aliases | eukaryotic translation initiation factor 4A1 |
| Synonyms | BM-010, DDX2A, Eif4, EIF-4A, eIF4AI, Elongation factor 4 alpha, Elongation factor 4 α, eukaryotic translation initiation factor 4A1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Eif4a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- nucleic acid binding translation factor
- RNA cap binding
- mRNA binding
- helicase
- DEAD/DEAH box helicase
- helicase superfamily c-terminal domain
- protein binding
- Helicase conserved C-terminal domain
- translation regulator
- double-stranded RNA binding
- N-terminal helicase domain of the DEAD-box helicase superfamily
- translation initiation factor
- DEAD-like helicases superfamily
- P-loop containing Nucleoside Triphosphate Hydrolases
Pathways
Biological processes and signaling networks where the Eif4a1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteosarcomagenesis
- breast cancer
- epithelial cancer
- neoplasia
- organismal death
- prostate cancer
- ductal breast carcinoma
- ductal breast cancer
- osteosarcoma
- non-small cell lung carcinoma
role in cell
- apoptosis
- expression in
- proliferation
- cell viability
- growth
- synthesis in
- survival
- binding
- invasion by
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- interchromatin granule cluster fractions
- ribonucleoprotein granule
- perinuclear region
- Nucleus
- Plasma Membrane
- cytosol
- nucleoli
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Eif4a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cytoplasmic translational initiation
- translational initiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- eukaryotic translation initiation factor 4F complex
- cytoplasm
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- ATPase activity
- translation initiation factor activity
- ATP binding
- RNA binding
- protein binding
- RNA helicase activity
- double-stranded RNA binding
- RNA cap binding
- mRNA binding
- helicase activity
- translation factor activity, nucleic acid binding