Vps35 Gene Summary [Mouse]
Enables D1 dopamine receptor binding activity. Involved in several processes, including regulation of macromolecule metabolic process; regulation of protein localization; and regulation of synapse organization. Located in several cellular components, including neuronal cell body; perinuclear region of cytoplasm; and postsynaptic density. Part of retromer complex. Is active in several cellular components, including dopaminergic synapse; glutamatergic synapse; and postsynapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Used to study Parkinson's disease and Parkinson's disease 17. Human ortholog(s) of this gene implicated in Parkinson's disease and Parkinson's disease 17. Orthologous to human VPS35 (VPS35 retromer complex component). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vps35 |
| Official Name | VPS35 retromer complex component [Source:MGI Symbol;Acc:MGI:1890467] |
| Ensembl ID | ENSMUSG00000031696 |
| Bio databases IDs | |
| Aliases | VPS35 retromer complex component |
| Synonyms | MEM3, PARK17, VPS35 retromer complex component |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vps35 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Vacuolar protein sorting-associated protein 35
- G-protein-coupled receptor binding
- protein binding
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- metastasis
- Alzheimer disease
- schizophrenia
- neurodegeneration
- hereditary disorder
- gastric cancer
- organismal death
- amyotrophic lateral sclerosis
- Parkinson disease
- Parkinson disease type 17
role in cell
- activation in
- proliferation
- phosphorylation in
- migration
- expression in
- quantity
- apoptosis
- loss
- degradation in
- invasion by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- microsomal fraction
- membrane fraction
- glutaminergic synapse
- intracellular membrane-bounded organelle
- presynaptic regions
- perinuclear region
- postsynaptic region
- cellular membrane
- Nucleus
- Plasma Membrane
- endosomes
- lysosome
- Mitochondria
- cytosol
- endosomal membrane
- neurites
- nerve ending
- synapse
- early endosomes
- cytoplasmic vesicles
- perikaryon
- postsynaptic density
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vps35 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of dopamine receptor signaling pathway
- protein localization in endosome
- positive regulation of Wnt protein secretion
- intracellular protein transport
- regulation of protein metabolic process
- transcytosis
- Wnt receptor signaling pathway
- negative regulation of protein homooligomerization
- regulation of terminal button organization
- regulation of synapse maturation
- positive regulation of locomotion involved in locomotory behavior
- lysosome organization
- negative regulation of inflammatory response
- positive regulation of canonical Wnt receptor signaling pathway
- positive regulation of protein catabolic process
- mitochondrial fragmentation involved in apoptotic process
- positive regulation of mitochondrial fission
- retrograde transport, endosome to Golgi
- protein destabilization
- negative regulation of gene expression
- voluntary musculoskeletal movement
- regulation of protein stability
- positive regulation of gene expression
- regulation of macroautophagy
- regulation of synaptic transmission
- regulation of mitochondrion organization
- endocytic recycling
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- late endosome
- retromer complex, inner shell
- neuronal cell body
- neuron projection
- lysosomal membrane
- lysosome
- early endosome
- extracellular vesicular exosome
- perinuclear region of cytoplasm
- endosome
- retromer complex
- mitochondrion
- cytosol
- endosome membrane
Molecular Function
What the gene product does at the molecular level
- D1 dopamine receptor binding
- protein binding