Aadat Gene Summary [Mouse]
Predicted to enable protein homodimerization activity and transaminase activity. Predicted to be involved in 2-oxoglutarate metabolic process; glutamate metabolic process; and kynurenine metabolic process. Located in mitochondrion. Is expressed in several structures, including alimentary system; brain; heart; liver; and metanephros. Orthologous to human AADAT (aminoadipate aminotransferase). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Aadat |
| Official Name | aminoadipate aminotransferase [Source:MGI Symbol;Acc:MGI:1345167] |
| Ensembl ID | ENSMUSG00000057228 |
| Bio databases IDs | |
| Aliases | aminoadipate aminotransferase |
| Synonyms | Aadt, aminoadipate aminotransferase, KAT2, KATII, KYAT2, Kynurenine/alpha Aminoadipate Aminotransferase, Kynurenine/α Aminoadipate Aminotransferase, mKat-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Aadat often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tyrosine/nicotianamine family aminotransferase
- tyrosine aminotransferase, eukaryotic
- kynurenine-oxoglutarate transaminase
- protein homodimerization
- methionine-glyoxylate transaminase
- AAT_I
- enzyme
- Aminotransferase class I and II
- transaminase
- kynurenine-glyoxylate transaminase
- 2-aminoadipate transaminase
- glycine transaminase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- hyperactive behavior
regulates
- kynurenic acid
- L-glutamic acid
- kynurenine
- 2-oxoglutaric acid
- acetylcholine
role in cell
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Aadat gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutamate metabolic process
- kynurenine metabolic process
- biosynthetic process
- L-kynurenine metabolic process
- 2-oxoglutarate metabolic process
- L-lysine catabolic process to acetyl-CoA via saccharopine
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- protein homodimerization activity
- 2-aminoadipate transaminase activity
- kynurenine-glyoxylate transaminase activity
- methionine-glyoxylate transaminase activity
- kynurenine-oxoglutarate transaminase activity
- glycine:2-oxoglutarate aminotransferase activity