AADAT Gene Summary [Human]
This gene encodes a protein that is highly similar to mouse and rat kynurenine aminotransferase II. The rat protein is a homodimer with two transaminase activities. One activity is the transamination of alpha-aminoadipic acid, a final step in the saccaropine pathway which is the major pathway for L-lysine catabolism. The other activity involves the transamination of kynurenine to produce kynurenine acid, the precursor of kynurenic acid which has neuroprotective properties. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Details
| Type | Protein Coding |
| Official Symbol | AADAT |
| Official Name | aminoadipate aminotransferase [Source:HGNC Symbol;Acc:HGNC:17929] |
| Ensembl ID | ENSG00000109576 |
| Bio databases IDs | |
| Aliases | aminoadipate aminotransferase, kynurenine aminotransferase II, L kynurenine/alpha aminoadipate aminotransferase |
| Synonyms | Aadt, aminoadipate aminotransferase, KAT2, KATII, KYAT2, Kynurenine/alpha Aminoadipate Aminotransferase, Kynurenine/α Aminoadipate Aminotransferase, mKat-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human AADAT often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- tyrosine/nicotianamine family aminotransferase
- tyrosine aminotransferase, eukaryotic
- kynurenine-oxoglutarate transaminase
- protein homodimerization
- methionine-glyoxylate transaminase
- AAT_I
- enzyme
- Aminotransferase class I and II
- transaminase
- kynurenine-glyoxylate transaminase
- 2-aminoadipate transaminase
- glycine transaminase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
- hyperactive behavior
regulates
- kynurenic acid
- L-glutamic acid
- kynurenine
- 2-oxoglutaric acid
- acetylcholine
role in cell
- abnormal morphology
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Mitochondria
- cytosol
- mitochondrial matrix
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human AADAT gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- glutamate metabolic process
- kynurenine metabolic process
- biosynthetic process
- L-kynurenine metabolic process
- 2-oxoglutarate metabolic process
- L-lysine catabolic process to acetyl-CoA via saccharopine
Cellular Component
Where in the cell the gene product is active
- mitochondrial matrix
Molecular Function
What the gene product does at the molecular level
- pyridoxal phosphate binding
- protein homodimerization activity
- 2-aminoadipate transaminase activity
- kynurenine-glyoxylate transaminase activity
- methionine-glyoxylate transaminase activity
- kynurenine-oxoglutarate transaminase activity
- glycine:2-oxoglutarate aminotransferase activity