Spaca3 Gene Summary [Mouse]
Predicted to enable lysozyme activity. Involved in fusion of sperm to egg plasma membrane involved in single fertilization. Acts upstream of or within sperm-egg recognition. Located in acrosomal vesicle. Orthologous to human SPACA3 (sperm acrosome associated 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Spaca3 |
| Official Name | sperm acrosome associated 3 [Source:MGI Symbol;Acc:MGI:1922872] |
| Ensembl ID | ENSMUSG00000053184 |
| Bio databases IDs | |
| Aliases | sperm acrosome associated 3 |
| Synonyms | 1700025M08RIK, ALLP17, CT54, LYC3, LYZC, LYZL3, mSLLP1, SLLP1, sperm acrosome associated 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Spaca3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- lysozyme-like domains
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- acrosome
- secretory granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Spaca3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- sperm-egg recognition
- positive regulation of macrophage activation
- fusion of sperm to egg plasma membrane
- positive regulation of phagocytosis
- monocyte activation
Cellular Component
Where in the cell the gene product is active
- acrosomal membrane
- acrosomal vesicle
- secretory granule
- sperm flagellum
- extracellular region
- acrosomal matrix
Molecular Function
What the gene product does at the molecular level
- protein binding
- lysozyme activity