Rpl38 Gene Summary [Mouse]
A structural constituent of ribosome. Acts upstream of or within several processes, including 90S preribosome assembly; middle ear morphogenesis; and sensory perception of sound. Located in cytoplasm. Part of cytosolic large ribosomal subunit and eukaryotic 80S initiation complex. Is active in synapse. Is expressed in thymus primordium. Used to study otitis media. Orthologous to human RPL38 (ribosomal protein L38). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rpl38 |
| Official Name | ribosomal protein L38 [Source:MGI Symbol;Acc:MGI:1914921] |
| Ensembl ID | ENSMUSG00000057322 |
| Bio databases IDs | |
| Aliases | ribosomal protein L38 |
| Synonyms | 0610025G13RIK, eL38, L38, LOC688248, RBT, ribosomal protein L38, Ts, TSS |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rpl38 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of ribosome
- protein binding
- Ribosomal L38e protein family
- RNA binding
Pathways
Biological processes and signaling networks where the Rpl38 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- flu
phenotypes
- abnormal auditory tube morphology
- abnormal autopod morphology
- abnormal blastocoele morphology
- abnormal blastocyst morphology
- abnormal cervical atlas morphology
- abnormal cervical vertebrae morphology
- abnormal cranium morphology
- abnormal digit morphology
- abnormal distortion product otoacoustic emission
- abnormal embryonic erythropoiesis
- abnormal forelimb morphology
- abnormal hearing physiology
- abnormal heart development
- abnormal humerus morphology
- abnormal metacarpal bone morphology
- abnormal metatarsal bone morphology
- abnormal middle ear morphology
- abnormal nasal bone morphology
- abnormal nasal cavity morphology
- abnormal neural tube morphology
- abnormal neuromere morphology
- abnormal notochord morphology
- abnormal nucleolus morphology
- abnormal olfactory bulb morphology
- abnormal oval window morphology
- abnormal placenta vasculature
- abnormal preimplantation embryo development
- abnormal rib morphology
- abnormal round window morphology
- abnormal sacral vertebrae morphology
- abnormal sternebra morphology
- abnormal tail morphology
- abnormal vertebrae development
- abnormal vertebral arch morphology
- abnormal vertebral lamina morphology
- abnormal vertebral pedicle morphology
- abnormal vertebral spinous process morphology
- abnormal vertebral transverse process morphology
- abnormal vitelline vasculature morphology
- absent blastocoele
- absent caudal vertebrae
- absent tail
- anemia
- anencephaly
- asymmetric sternocostal joints
- belly spot
- caudal vertebral fusion
- caudal vertebral transformation
- cervical vertebral fusion
- cleft palate
- cleft upper lip
- conductive hearing loss
- curly tail
- decreased body length
- decreased body size
- decreased body weight
- decreased caudal vertebrae number
- decreased cranium height
- decreased embryo size
- decreased length of long bones
- embryonic growth arrest
- embryonic growth retardation
- embryonic lethality at implantation incomplete penetrance
- embryonic lethality between implantation and somite formation complete penetrance
- embryonic lethality complete penetrance
- exencephaly
- herniated abdominal wall
- incomplete rostral neuropore closure
- increased circulating phosphate level
- increased cranium width
- increased or absent threshold for auditory brainstem response
- increased rib number
- increased sternebra number
- increased susceptibility to otitis media
- increased thoracic vertebrae number
- irregular coat pigmentation
- kinked tail
- lumbar vertebral transformation
- oligodactyly
- omphalocele
- perinatal lethality incomplete penetrance
- polydactyly
- postnatal growth retardation
- postnatal lethality complete penetrance
- prenatal lethality complete penetrance
- prenatal lethality incomplete penetrance
- reduced fertility
- rib fusion
- sacral vertebral transformation
- short femur
- short humerus
- short radius
- short snout
- short tail
- short tibia
- small caudal vertebrae
- spina bifida
- sternebra fusion
- vertebral fusion
- vertebral transformation
- wavy neural tube
role in cell
- cell viability
- cell death
- ossification by
- translation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- ribosome
- cytosol
- synapse
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rpl38 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- sensory perception of sound
- skeletal system development
- 90S preribosome assembly
- ossification
- cytoplasmic translation
- ribonucleoprotein complex assembly
- middle ear morphogenesis
- translation
- axial mesoderm development
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- eukaryotic 80S initiation complex
- cytosolic ribosome
- focal adhesion
- cytoplasm
- cytosol
- cytosolic large ribosomal subunit
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding
- structural constituent of ribosome