Vsir Gene Summary [Mouse]
Predicted to enable endopeptidase activator activity; enzyme binding activity; and identical protein binding activity. Acts upstream of or within several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; negative regulation of T cell cytokine production; and positive regulation of BMP signaling pathway. Located in external side of plasma membrane. Is expressed in several structures, including immune system; liver; lung; male reproductive gland or organ; and small intestine lamina propria. Orthologous to human VSIR (V-set immunoregulatory receptor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Vsir |
| Official Name | V-set immunoregulatory receptor [Source:MGI Symbol;Acc:MGI:1921298] |
| Ensembl ID | ENSMUSG00000020101 |
| Bio databases IDs | |
| Aliases | V-set immunoregulatory receptor |
| Synonyms | 4632428N05Rik, B7-H5, C10orf54, DD1alpha, Dies1, GI24, IMAGE 4158410, LOC679150, MGC112715, PD-1H, PP2135, SISP1, VISTA, V-set immunoregulatory receptor |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Vsir often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- RXXs motif
- immunoglobulin domain
- Immunoglobulin like
- enzyme binding
- protein binding
- enzyme regulator activity
- protease activator
- identical protein binding
- Immunoglobulin V-set domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- neoplasia
- colon cancer
- autoimmune disease
- chronic inflammation
- experimental autoimmune encephalomyelitis
role in cell
- production in
- expression in
- activation
- proliferation
- accumulation
- migration
- differentiation
- cytolysis
- adipogenesis
- cytolysis by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- plasma membrane extracellular face
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Vsir gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-10 production
- negative regulation of alpha-beta T cell activation
- positive regulation of regulatory T cell differentiation
- zymogen activation
- positive regulation of gene expression
- negative regulation of CD8-positive, alpha-beta T cell proliferation
- negative regulation of interferon-gamma production
- negative regulation of interleukin-17 production
- negative regulation of CD4-positive, alpha-beta T cell proliferation
- positive regulation of endopeptidase activity
- negative regulation of tumor necrosis factor production
- positive regulation of cell migration
- regulation of immune response
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- endopeptidase activator activity
- identical protein binding
- protein binding
- enzyme binding