Chsy3 Gene Summary [Mouse]
Enables N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity and glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity. Involved in chondroitin sulfate proteoglycan biosynthetic process. Is active in Golgi apparatus. Is expressed in articular cartilage; cartilage; cerebral cortex; and humerus. Orthologous to human CHSY3 (chondroitin sulfate synthase 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Chsy3 |
| Official Name | chondroitin sulfate synthase 3 [Source:MGI Symbol;Acc:MGI:1926173] |
| Ensembl ID | ENSMUSG00000058152 |
| Bio databases IDs | |
| Aliases | chondroitin sulfate synthase 3 |
| Synonyms | 4833446K15Rik, chondroitin sulfate synthase 3, chondroitin sulphate synthase 3, CHSY2, Chsy3l, CSS3, RGD1560819 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chsy3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase
- Chondroitin N-acetylgalactosaminyltransferase
- galactosyltransferase
- N-terminal domain of galactosyltransferase
- glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase
- enzyme
- glucuronyl-N-acetylgalactosaminylproteoglycan beta-1,4-N-acetylgalactosaminyltransferase
- glycosyltransferase family A
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Golgi Apparatus
- Golgi membrane
- Golgi stacks
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chsy3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- chondroitin sulfate biosynthetic process
Cellular Component
Where in the cell the gene product is active
- Golgi cisterna membrane
- Golgi membrane
Molecular Function
What the gene product does at the molecular level
- N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity
- metal ion binding
- glucuronosyl-N-acetylgalactosaminyl-proteoglycan 4-beta-N-acetylgalactosaminyltransferase activity