Golph3 Gene Summary [Mouse]
Predicted to enable cargo adaptor activity; enzyme binding activity; and phosphatidylinositol-4-phosphate binding activity. Predicted to be involved in several processes, including Golgi vesicle transport; cell adhesion molecule production; and protein localization to Golgi apparatus. Located in Golgi apparatus. Is expressed in several structures, including brain; limb; liver; and notochord. Orthologous to human GOLPH3 (golgi phosphoprotein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Golph3 |
| Official Name | golgi phosphoprotein 3 [Source:MGI Symbol;Acc:MGI:1913879] |
| Ensembl ID | ENSMUSG00000022200 |
| Bio databases IDs | |
| Aliases | golgi phosphoprotein 3 |
| Synonyms | 4733401N08Rik, 5730410D03Rik, GMX33, golgi phosphoprotein 3, GOPP1, GPP34, MIDAS, Vps74 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Golph3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding activity, bridging
- enzyme binding
- Golgi phosphoprotein 3 (GPP34)
- protein binding
- phosphatidylinositol binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- non-small cell lung cancer
- metastasis
- rheumatoid arthritis
- MELAS syndrome
- chronic progressive external ophthalmoplegia
- infection by HIV-1
- productive infection by HIV-1
role in cell
- expression in
- phosphorylation in
- apoptosis
- growth
- proliferation
- migration
- survival
- morphology
- mass
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- juxtanuclear Golgi region
- intracellular membrane-bounded organelle
- perinuclear region
- Plasma Membrane
- endosomes
- Golgi Apparatus
- Mitochondria
- cytosol
- Golgi membrane
- Golgi stacks
- trans Golgi network
- mitochondrial intermembrane space
- Golgi cisternae
- cis Golgi cisternae
- trans Golgi cisternae
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Golph3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell adhesion molecule production
- glycoprotein biosynthetic process
- retrograde vesicle-mediated transport, Golgi to ER
- Golgi organization
- asymmetric Golgi ribbon formation
- Golgi to plasma membrane protein transport
- protein secretion
- Golgi ribbon formation
- protein retention in Golgi apparatus
- negative regulation of apoptotic process
- gene expression
- lamellipodium assembly
- leukocyte tethering or rolling
- regulation of mitochondrion organization
- positive regulation of protein secretion
- Golgi vesicle budding
- cell migration
- positive regulation of TOR signaling cascade
Cellular Component
Where in the cell the gene product is active
- trans-Golgi network
- mitochondrial intermembrane space
- endosome
- Golgi cisterna membrane
- intracellular membrane-bounded organelle
- mitochondrion
- cytosol
- Golgi apparatus
- Golgi membrane
- Golgi cisterna
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylinositol-4-phosphate binding
- protein binding
- enzyme binding