Krt6a Gene Summary [Mouse]
Predicted to be a structural constituent of skin epidermis. Involved in defense response to other organism; morphogenesis of an epithelium; and wound healing. Acts upstream of or within Wnt signaling pathway; intermediate filament organization; and keratinization. Predicted to be active in keratin filament. Is expressed in alimentary system; genitourinary system; sensory organ; and skin. Human ortholog(s) of this gene implicated in focal or diffuse nonepidermolytic palmoplantar keratoderma and pachyonychia congenita. Orthologous to several human genes including KRT6B (keratin 6B). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Krt6a |
| Official Name | keratin 6A [Source:MGI Symbol;Acc:MGI:1100845] |
| Ensembl ID | ENSMUSG00000058354 |
| Bio databases IDs | |
| Aliases | keratin 6A |
| Synonyms | 2310016L08Rik, CK-6A, CK-6C, CK6D, CK-6E, K6, K6A, K6[a], K6alpha, K6C, K6D, Keratin6, KERATIN 6A, Krt2-6a, Krt2-6c, Krt6, KRT6C, KRT6D, MK6a, mK6[a], PC3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Krt6a often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- Intermediate filament protein
- Keratin type II head
Pathways
Biological processes and signaling networks where the Krt6a gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- dermatological disorder
- pachyonychia congenita 3
- non-small cell lung cancer
- organismal death
- autosomal dominant polycystic kidney disease
- lichen planus
- plaque psoriasis
- lung cancer
- psoriasis
regulates
- F Actin
role in cell
- rupture
- migration
- damage
- organization
- abnormal morphology
- epithelialization
- cytolysis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- detergent resistant lipid raft fraction
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Krt6a gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- wound healing
- negative regulation of entry of bacterium into host cell
- morphogenesis of an epithelium
- positive regulation of cell proliferation
- killing of cells of other organism
- cell differentiation
- keratinization
- intermediate filament organization
- defense response to Gram-positive bacterium
Cellular Component
Where in the cell the gene product is active
- nucleus
- extracellular vesicular exosome
- keratin filament
- membrane
- cytosol
Molecular Function
What the gene product does at the molecular level
- structural constituent of epidermis
- protein binding
- structural constituent of cytoskeleton