Krt17 Gene Summary [Mouse]
The protein encoded by this gene is a member of the type I keratin gene family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The encoded protein is a cytokeratin required for the normal growth of hair follicles and may act in psoriasis as an immunopathogenic autoantigen. [provided by RefSeq, Sep 2015]
Details
| Type | Protein Coding |
| Official Symbol | Krt17 |
| Official Name | keratin 17 [Source:MGI Symbol;Acc:MGI:96691] |
| Ensembl ID | ENSMUSG00000035557 |
| Bio databases IDs | |
| Aliases | keratin 17 |
| Synonyms | 39.1, CK-17, K17, Ka17, keratin 17, KRT1-17, PC, PC2, PCHC1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Krt17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- structural constituent of cytoskeleton
- protein binding
- Intermediate filament protein
Pathways
Biological processes and signaling networks where the Krt17 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- diabetes mellitus
- systemic sclerosis
- hyperplasia
- lymphatic neoplasia
- epithelial cancer
- epithelial neoplasia
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- cervical cancer
- psoriasis
role in cell
- proliferation
- expression in
- formation
- binding in
- growth
- morphology
- migration
- signaling in
- formation in
- upregulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- cornified envelope
- intermediate filament cytoskeleton
- cell periphery
- intermediate filaments
- keratin filament networks
- cytosol
- nucleoli
- nuclear scaffolds
- keratin intermediate filaments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Krt17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- epithelial cell differentiation
- positive regulation of cell growth
- positive regulation of translation
- hair follicle morphogenesis
- keratinization
- intermediate filament organization
- positive regulation of hair follicle development
Cellular Component
Where in the cell the gene product is active
- cornified envelope
- cytoskeleton
- keratin filament
- intermediate filament cytoskeleton
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding
- structural molecule activity