Frem1 Gene Summary [Mouse]
Predicted to enable carbohydrate binding activity and metal ion binding activity. Acts upstream of or within cell-matrix adhesion. Located in basement membrane. Is expressed in several structures, including alimentary system; bone; brain; sensory organ; and skin. Used to study Fraser syndrome; chromosome 9p deletion syndrome; and congenital diaphragmatic hernia. Human ortholog(s) of this gene implicated in congenital diaphragmatic hernia. Orthologous to human FREM1 (FRAS1 related extracellular matrix 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Frem1 |
| Official Name | Fras1 related extracellular matrix protein 1 [Source:MGI Symbol;Acc:MGI:2670972] |
| Ensembl ID | ENSMUSG00000059049 |
| Bio databases IDs | |
| Aliases | Fras1 related extracellular matrix protein 1 |
| Synonyms | BNAR, C9orf143, C9orf145, C9orf154, crf11, D430009N09, D630008K06, eye<m02Jus>, eyes2, FRAS1 related extracellular matrix 1, Fras1 related extracellular matrix protein 1, heb, MOTA, qbrick, RGD1306981, TRIGNO2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Frem1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- C-type lectin (CTL)/C-type lectin-like (CTLD) domain
- Cadherin-like
- Frem protein N-terminal domain
- Lectin C-type domain
- protein binding
- Calx-beta domain
- Domains in Na-Ca exchangers and integrin-beta4
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- breast cancer
- hereditary disorder
- bifid nose with or without anorectal and renal anomalies
- chronic lymphocytic leukemia
- metabolic syndrome X
- Manitoba oculotrichoanal syndrome
- familial myeloproliferative neoplasm
- myeloproliferative disorder
- bone marrow cancer
- hereditary cancer
role in cell
- binding
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Frem1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- cell communication
- anatomical structure morphogenesis
- craniofacial suture morphogenesis
Cellular Component
Where in the cell the gene product is active
- basement membrane
- membrane
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- metal ion binding
- carbohydrate binding