Egfl6 Gene Summary [Mouse]
Predicted to enable calcium ion binding activity. Acts upstream of or within extracellular matrix organization and positive regulation of cell-substrate adhesion. Located in basement membrane. Is expressed in several structures, including alimentary system; genitourinary system; limb; lung; and skin. Orthologous to human EGFL6 (EGF like domain multiple 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Egfl6 |
| Official Name | EGF-like-domain, multiple 6 [Source:MGI Symbol;Acc:MGI:1858599] |
| Ensembl ID | ENSMUSG00000000402 |
| Bio databases IDs | |
| Aliases | EGF-like-domain, multiple 6 |
| Synonyms | EGF like domain multiple 6, EGF-like-domain, multiple 6, MAEG, W80 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Egfl6 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
- integrin binding
- EGF domain
- protein binding
- MAM domain, meprin/A5/mu
- Coagulation Factor Xa inhibitory site
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- oral squamous cell carcinoma
- squamous cell cancer of the oral cavity
- multiple sclerosis
regulates
- ERK
- PTPN11
role in cell
- migration
- number
- angiogenesis
- organization
- asymmetric division
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- extracellular matrix
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Egfl6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell differentiation
- extracellular matrix organization
- cell adhesion
- positive regulation of cell-substrate adhesion
Cellular Component
Where in the cell the gene product is active
- basement membrane
- extracellular space
- membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium ion binding
- integrin binding