Fras1 Gene Summary [Mouse]
Predicted to enable metal ion binding activity. Predicted to be an extracellular matrix structural constituent. Acts upstream of or within several processes, including embryonic limb morphogenesis; metanephros morphogenesis; and roof of mouth development. Located in basement membrane. Is expressed in several structures, including alimentary system; body cavity or lining; brain; sensory organ; and skin. Used to study Fraser syndrome and clubfoot. Human ortholog(s) of this gene implicated in Fraser syndrome 1. Orthologous to human FRAS1 (Fraser extracellular matrix complex subunit 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Fras1 |
| Official Name | Fraser extracellular matrix complex subunit 1 [Source:MGI Symbol;Acc:MGI:2385368] |
| Ensembl ID | ENSMUSG00000034687 |
| Bio databases IDs | |
| Aliases | Fraser extracellular matrix complex subunit 1 |
| Synonyms | bl, E130113P14Rik, Fraser extracellular matrix complex subunit 1, FRASRS1, LOC103693728, mKIAA1500 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Fras1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Giardia variant-specific surface protein
- Cadherin-like
- Growth factor receptor domain IV
- Furin-like cysteine rich region
- Bacterial Ig domain
- protein binding
- Tumor necrosis factor receptor superfamily (TNFRSF)
- Domains in Na-Ca exchangers and integrin-beta4
- FU
- von Willebrand factor type C domain
- cytoplasmic domain
- Furin-like repeat, cysteine-rich
- Furin-like repeats
- Calx-beta domain
- Cell surface immobilization antigen SerH
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Fraser syndrome type 1
- chronic obstructive pulmonary disease
- agenesis
- COVID-19
- congenital anomalies of kidney and urinary tract
- bleeding
- lung adenocarcinoma
- lung adenocarcinoma formation
- myopia
- cryptophthalmos syndrome
phenotypes
- abnormal basement membrane morphology
- abnormal digit morphology
- abnormal eye morphology
- abnormal glomerular capillary morphology
- abnormal glomerular capsule space morphology
- abnormal glomerular mesangium morphology
- abnormal hair growth
- abnormal kidney development
- abnormal lung development
- abnormal lung epithelium morphology
- abnormal lung morphology
- abnormal lung vasculature morphology
- abnormal metanephric mesenchyme morphology
- abnormal metanephros morphology
- abnormal palatal shelf fusion at midline
- abnormal renal glomerulus morphology
- abnormal rib morphology
- abnormal secondary palate development
- abnormal sternebra morphology
- abnormal sternum morphology
- abnormal ureteric bud morphology
- absent kidney
- bleb
- blistering
- cleft secondary palate
- clubfoot
- cortical renal glomerulopathies
- cryptophthalmos
- delayed kidney development
- eyelids open at birth
- fetal bleb
- fused right lung lobes
- glomerulosclerosis
- hemorrhage
- impaired branching involved in ureteric bud morphogenesis
- increased metanephric mesenchyme apoptosis
- kidney cysts
- lethality throughout fetal growth and development complete penetrance
- lethality throughout fetal growth and development incomplete penetrance
- micrognathia
- microphthalmia
- narrow eye opening
- perimembraneous ventricular septal defect
- preaxial polydactyly
- prenatal lethality incomplete penetrance
- single kidney
- small kidney
- syndactyly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cellular membrane
- vesicles
- basal cell surfaces
- extracellular matrix
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Fras1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- embryonic limb morphogenesis
- metanephros morphogenesis
- cell communication
- morphogenesis of an epithelium
- palate development
- protein transport
- anatomical structure morphogenesis
- skin development
Cellular Component
Where in the cell the gene product is active
- basement membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- metal ion binding