Npnt Gene Summary [Mouse]
Enables integrin binding activity. Involved in several processes, including cell-cell adhesion mediated by integrin; pilomotor reflex; and positive regulation of metabolic process. Acts upstream of or within several processes, including branching involved in ureteric bud morphogenesis; positive regulation of cell-substrate adhesion; and positive regulation of transforming growth factor beta receptor signaling pathway. Located in several cellular components, including basement membrane; collagen-containing extracellular matrix; and smooth muscle contractile fiber. Is expressed in several structures, including alimentary system; brain; genitourinary system; respiratory system; and sensory organ. Used to study bilateral renal aplasia. Orthologous to human NPNT (nephronectin). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Npnt |
| Official Name | nephronectin [Source:MGI Symbol;Acc:MGI:2148811] |
| Ensembl ID | ENSMUSG00000040998 |
| Bio databases IDs | |
| Aliases | nephronectin |
| Synonyms | 1110009H02Rik, EGFL6L, LOC686753, Nctn, nephronectin, POEM |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Npnt often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
- Complement Clr-like EGF-like
- integrin binding
- RGD motif
- EGF domain
- EGF-like domain
- MAM domain, meprin/A5/mu
- Coagulation Factor Xa inhibitory site
- EGF_CA
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- asthma
- hypertension
- non-small cell lung cancer
- COVID-19
- preeclampsia
- atherosclerosis
- cardiovascular disorder
- major depression
- agenesis
role in cell
- differentiation
- survival
- apoptosis
- production in
- development
- adhesion
- organization
- response by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- myofibrils
- extracellular matrix
- basal lamina
- basement membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Npnt gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell-matrix adhesion
- transforming growth factor beta receptor signaling pathway
- pilomotor reflex
- positive regulation of osteoblast differentiation
- positive regulation of transcription from RNA polymerase II promoter
- positive regulation of smooth muscle contraction
- establishment of protein localization
- smooth muscle cell differentiation
- ureteric bud development
- branching involved in ureteric bud morphogenesis
- positive regulation of ERK1 and ERK2 cascade
- extracellular matrix organization
- cell-cell adhesion mediated by integrin
- positive regulation of cell-substrate adhesion
- cellular response to tumor necrosis factor
- positive regulation of transforming growth factor beta receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- basement membrane
- extracellular vesicular exosome
- membrane
- smooth muscle contractile fiber
- extracellular region
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- integrin binding
- extracellular matrix structural constituent