Letm1 Gene Summary [Mouse]
Enables calcium:proton antiporter activity. Involved in calcium export from the mitochondrion; mitochondrial calcium ion homeostasis; and protein complex oligomerization. Located in mitochondrial inner membrane. Is expressed in brain; embryo; gonad; liver; and seminiferous cord. Orthologous to human LETM1 (leucine zipper and EF-hand containing transmembrane protein 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Letm1 |
| Official Name | leucine zipper-EF-hand containing transmembrane protein 1 [Source:MGI Symbol;Acc:MGI:1932557] |
| Ensembl ID | ENSMUSG00000005299 |
| Bio databases IDs | |
| Aliases | leucine zipper-EF-hand containing transmembrane protein 1 |
| Synonyms | CONDMIM, KHE, leucine zipper and EF-hand containing transmembrane protein 1, leucine zipper-EF-hand containing transmembrane protein 1, Mdm38, SLC55A1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Letm1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium:hydrogen antiporter
- LETM1-like, RBD
- calcium ion binding
- protein binding
- transporter
- Dockerin repeat domains and domains resembling dockerin repeats
Pathways
Biological processes and signaling networks where the Letm1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cervical cancer
- breast cancer
- lung cancer
- liver cancer
- esophageal cancer
- gastric cancer
- ovarian cancer
- childhood-onset neurodegeneration with multisystem involvement due to mitochondrial dysfunction
- colon cancer
- Wolf-Hirschhorn syndrome
role in cell
- expression in
- production in
- activation in
- phosphorylation in
- cell death
- formation
- mass
- cell cycle progression
- autophagy by
- inactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- pH resistant lipid raft fraction
- Nucleus
- Mitochondria
- mitochondrial membrane
- mitochondrial inner membrane
- growth cone
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Letm1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cristae formation
- reduction of mitochondrial calcium ion concentration
- mitochondrial calcium ion homeostasis
- calcium ion transport
- protein homooligomerization
- regulation of cellular hyperosmotic salinity response
- protein hexamerization
- inner mitochondrial membrane organization
- cellular cation homeostasis
- mitochondrial calcium ion transport
Cellular Component
Where in the cell the gene product is active
- mitochondrion
- mitochondrial inner membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- ribosome binding
- calcium ion binding
- calcium:hydrogen antiporter activity