Hopx Gene Summary [Mouse]
Enables histone deacetylase regulator activity. Involved in positive regulation of gap junction assembly. Acts upstream of or within several processes, including lung alveolus development; positive regulation of skeletal muscle tissue regeneration; and trophectodermal cell differentiation. Located in nucleus. Is expressed in several structures, including central nervous system; epithelium; heart; trophectoderm; and urinary system. Orthologous to human HOPX (HOP homeobox). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Hopx |
| Official Name | HOP homeobox [Source:MGI Symbol;Acc:MGI:1916782] |
| Ensembl ID | ENSMUSG00000059325 |
| Bio databases IDs | |
| Aliases | HOP homeobox |
| Synonyms | 1110018K11Rik, 1200015P04Rik, 2300002F06Rik, CAMEO, GIIg15b, Hdop, HOD, HOP, HOP homeobox, Hop/necc1, LAGY, LOC103693743, Mgi:1916782, NECC1, OB1, Obl, SMAP31, TOTO |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Hopx often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- histone deacetylase regulator
- transcription regulator
- alpha helix
- protein binding
- homeodomain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- esophageal squamous cell carcinoma
- esophageal squamous cell cancer
- diabetic nephropathy
- cardiac fibrosis
- chronic obstructive pulmonary disease
- male pattern hair loss
- cleft lip
- uterine leiomyoma
- leiomyomatosis
role in cell
- differentiation
- formation
- cell viability
- assembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Hopx gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- lung alveolus development
- negative regulation of cell differentiation
- positive regulation of striated muscle cell differentiation
- chaperone-mediated protein complex assembly
- regulation of heart contraction
- trophectodermal cell differentiation
- bundle of His development
- positive regulation of skeletal muscle tissue regeneration
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
- chromatin
Molecular Function
What the gene product does at the molecular level
- histone deacetylase regulator activity
- DNA binding
- protein binding