Mta2 Gene Summary [Mouse]
Enables histone deacetylase activity and transcription coregulator activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within genomic imprinting; negative regulation of transcription by RNA polymerase II; and positive regulation of transcription by RNA polymerase II. Located in nucleus. Part of NuRD complex. Is expressed in several structures, including central nervous system; early conceptus; genitourinary system; limb; and retina. Used to study systemic lupus erythematosus. Orthologous to human MTA2 (metastasis associated 1 family member 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mta2 |
| Official Name | metastasis-associated gene family, member 2 [Source:MGI Symbol;Acc:MGI:1346340] |
| Ensembl ID | ENSMUSG00000071646 |
| Bio databases IDs | |
| Aliases | metastasis-associated gene family, member 2 |
| Synonyms | Mata1l1, metastasis associated 1 family member 2, metastasis associated 1 family, member 2, metastasis-associated gene family, member 2, mmta2, MTA1-L1, MTA-L1, PID |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mta2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SANT
- transcription regulator
- SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
- transcription cofactor
- MTA R1 domain
- transcription factor binding
- histone deacetylase binding
- protein binding
- BAH
- BAH domain
- ELM2 domain
- Myb-like DNA-binding domain
- histone deacetylase
- zinc finger binding to DNA consensus sequence [AT]GATA[AG]
- ZnF_GATA
Pathways
Biological processes and signaling networks where the Mta2 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hyperplasia
- hyperkeratosis
- panniculitis
- systemic lupus erythematosus
- acanthosis
- glomerulonephritis
- dermatitis
- proteinuria
role in cell
- expression in
- proliferation
- apoptosis
- growth
- phagocytosis by
- function
- remodeling
- organization
- phagocytosis
- migration by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- telomeres
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mta2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- chromatin remodeling
- regulation of cell fate specification
- negative regulation of transcription, DNA-dependent
- positive regulation of transcription, DNA-dependent
- regulation of stem cell differentiation
- positive regulation of transcription from RNA polymerase II promoter
- chromatin organization
- regulation of fibroblast migration
Cellular Component
Where in the cell the gene product is active
- transcription factor complex
- chromosome, telomeric region
- nucleus
- membrane
- NuRD complex
- histone deacetylase complex
- macromolecular complex
- chromatin
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- transcription coactivator activity
- histone deacetylase activity
- histone deacetylase binding
- transcription corepressor activity
- metal ion binding
- nucleosomal DNA binding
- sequence-specific DNA binding