Syn3 Gene Summary [Mouse]
Predicted to enable ATP binding activity. Involved in synaptic vesicle clustering. Located in postsynaptic density and synaptic vesicle membrane. Is active in glutamatergic synapse. Is expressed in several structures, including brain; genitourinary system; gut; respiratory system; and skeletal muscle. Used to study autism spectrum disorder and epilepsy. Orthologous to human SYN3 (synapsin III). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Syn3 |
| Official Name | synapsin III [Source:MGI Symbol;Acc:MGI:1351334] |
| Ensembl ID | ENSMUSG00000059602 |
| Bio databases IDs | |
| Aliases | synapsin III |
| Synonyms | LOC100910134, synapsin III |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Syn3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- ATP binding
- Synapsin N-terminal
- protein binding
- alpha-L-glutamate ligase, RimK family
- Synapsin, N-terminal domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- schizophrenia
- bipolar disorder
- insomnia
- chronic obstructive pulmonary disease
- COVID-19
- acne
- coronary artery disease
- tonic-clonic seizure
- benign prostatic hyperplasia
- cerebral aneurysm
role in cell
- growth
- synaptic depression
- outgrowth
- synaptic fatigue
- clustering
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- synaptic vesicle membrane
- glutaminergic synapse
- Cytoplasm
- cellular membrane
- synaptic vesicles
- dendrite initial segments
- synaptosomes
- synapse
- perikaryon
- axons
- dendrites
- postsynaptic density
- mossy fiber boutons
- vesicle fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Syn3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic vesicle clustering
- regulation of synaptic transmission, GABAergic
- neurotransmitter secretion
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- synaptic vesicle
- synaptic vesicle membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding