Syn2 Gene Summary [Mouse]
Enables identical protein binding activity. Involved in calcium-ion regulated exocytosis and synaptic vesicle clustering. Acts upstream of or within neurotransmitter secretion. Located in plasma membrane; postsynaptic density; and synaptic vesicle membrane. Part of SNARE complex. Is active in Schaffer collateral - CA1 synapse and glutamatergic synapse. Is expressed in several structures, including central nervous system; eye; genitourinary system; intercostal muscle; and nerve. Used to study autism spectrum disorder and epilepsy. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human SYN2 (synapsin II). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Retained Intron |
| Official Symbol | Syn2 |
| Official Name | synapsin II [Source:MGI Symbol;Acc:MGI:103020] |
| Ensembl ID | ENSMUSG00000009394 |
| Bio databases IDs | |
| Aliases | synapsin II |
| Synonyms | 2900074L19Rik, AI841723, synapsin II, SYNII |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Syn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- cytoskeletal protein binding
- Carbamoyl-phosphate synthase L chain, ATP binding domain
- ATP binding
- Synapsin N-terminal
- protein binding
- alpha-L-glutamate ligase, RimK family
- Synapsin, N-terminal domain
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- acne
- epithelial cancer
- chronic obstructive pulmonary disease
- COVID-19
- schizophrenia
- depressive disorder
- metabolic syndrome X
- tonic-clonic seizure
- idiopathic scoliosis
- seizures
role in cell
- formation
- synaptic depression
- activity
- transmission
- association
- maintenance
- clustering
- abnormal morphology
- abnormal quantity
- excitatory postsynaptic potential
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- myelin enriched fraction
- membrane fraction
- synaptic vesicle membrane
- glutaminergic synapse
- cellular membrane
- synaptic vesicles
- growth cone
- neurites
- synaptosomes
- synapse
- postsynaptic density
- synaptosomal fractions
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Syn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- synaptic transmission
- synaptic vesicle clustering
- calcium ion-dependent exocytosis
- neurotransmitter secretion
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- SNARE complex
- synapse
- synaptic vesicle membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- ATP binding
- identical protein binding
- protein binding