Flot1 Gene Summary [Mouse]
Predicted to enable ionotropic glutamate receptor binding activity and protease binding activity. Involved in several processes, including positive regulation of cell-cell adhesion mediated by cadherin; positive regulation of cellular component organization; and positive regulation of dopaminergic synaptic transmission. Acts upstream of or within axonogenesis and regulation of Rho protein signal transduction. Located in caveola; external side of plasma membrane; and sarcolemma. Part of flotillin complex. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human FLOT1 (flotillin 1). [provided by Alliance of Genome Resources, Apr 2025]
Details
| Type | Protein Coding |
| Official Symbol | Flot1 |
| Official Name | flotillin 1 [Source:MGI Symbol;Acc:MGI:1100500] |
| Ensembl ID | ENSMUSG00000059714 |
| Bio databases IDs | |
| Aliases | flotillin 1 |
| Synonyms | Flotillin-1, Rareg, reggie-2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Flot1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SPFH_like
- protease binding
- prohibitin homologues
- protein binding
- SPFH domain / Band 7 family
- ionotropic glutamate receptor binding
- hydrophobic domain
Pathways
Biological processes and signaling networks where the Flot1 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- atopic dermatitis
- schizophrenia
- major depression
- gastric cancer
- chronic obstructive pulmonary disease
- organismal death
- psoriasis
- hypothyroidism
role in cell
- proliferation
- morphology
- growth
- degradation in
- cell death
- assembly
- accumulation in
- formation
- activation in
- adhesion
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-insoluble membrane fraction
- high-density microsomal fractions
- myelin enriched fraction
- raft fractions
- caveolae fraction
- low-density microsomal fraction
- detergent-insoluble fractions
- detergent-soluble membrane fractions
- pH resistant lipid raft fraction
- detergent resistant lipid raft fraction
- glutaminergic synapse
- cortical actin cytoskeleton
- Cytoplasm
- presynaptic regions
- intracellular space
- apical compartment
- cellular membrane
- actin cytoskeleton
- membrane skeleton
- Nucleus
- endosomes
- centrosome
- lysosome
- Mitochondria
- intercellular junctions
- cell-cell contacts
- microtubule organizing centers
- membrane ruffles
- plasma membrane extracellular face
- caveolar membranes
- uropod
- caveolae
- plasma membrane projections
- basolateral membrane
- synapse
- Schmidt-Lanterman incisures
- sarcolemma
- early endosomes
- late endosomes
- cytoplasmic vesicles
- secretory vesicles
- membrane rafts
- detergent insoluble microdomains
- exosomes
- phagosomes
- cell-cell adherens junctions
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Flot1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of toll-like receptor 3 signaling pathway
- regulation of Rho protein signal transduction
- protein kinase C signaling cascade
- positive regulation of protein binding
- regulation of receptor internalization
- positive regulation of endocytosis
- extracellular matrix disassembly
- regulation of toll-like receptor 4 signaling pathway
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of neurotransmitter uptake
- cellular response to exogenous dsRNA
- positive regulation of skeletal muscle tissue development
- positive regulation of interferon-beta production
- axonogenesis
- positive regulation of protein phosphorylation
- positive regulation of heterotypic cell-cell adhesion
- protein stabilization
- positive regulation of cytokine production
- dsRNA transport
- positive regulation of cell-cell adhesion mediated by cadherin
- response to endoplasmic reticulum stress
- protein localization in plasma membrane
- positive regulation of synaptic transmission, dopaminergic
Cellular Component
Where in the cell the gene product is active
- centriolar satellite
- external side of plasma membrane
- caveola
- early endosome
- endosome
- extracellular vesicular exosome
- presynaptic active zone
- focal adhesion
- sarcolemma
- cytoplasmic vesicle
- signalosome
- cortical actin cytoskeleton
- lamellipodium
- lysosomal membrane
- plasma membrane
- cell-cell contact zone
- adherens junction
- cell-cell junction
- uropod
- microtubule organizing center
- melanosome
- membrane
- membrane raft
- basolateral plasma membrane
- apical plasma membrane
- flotillin complex
Molecular Function
What the gene product does at the molecular level
- ionotropic glutamate receptor binding
- protein binding
- protease binding