Chmp4b Gene Summary [Mouse]
Predicted to enable protein homodimerization activity. Involved in regulation of autophagy. Located in cytosol; endosome membrane; and nucleus. Is expressed in several structures, including branchial arch; central nervous system; limb bud; mandibular process; and sensory organ. Human ortholog(s) of this gene implicated in cataract 31 multiple types. Orthologous to several human genes including CHMP4B (charged multivesicular body protein 4B). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Processed Transcript |
| Official Symbol | Chmp4b |
| Official Name | charged multivesicular body protein 4B [Source:MGI Symbol;Acc:MGI:1922858] |
| Ensembl ID | ENSMUSG00000038467 |
| Bio databases IDs | |
| Aliases | charged multivesicular body protein 4B |
| Synonyms | 2010012F05RIK, C20orf178, C76846, charged multivesicular body protein 4B, CHMP4A, CTPP3, CTRCT31, dJ553F4.4, LOC683288, RGD1309846, RGD1565889, Shax1, SNF7, SNF7-2, Vps32-2, VPS32B |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Chmp4b often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PTZ00464
- protein homodimerization
- protein binding
- identical protein binding
- Snf7
Pathways
Biological processes and signaling networks where the Chmp4b gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- cancer
- melanoma
- melanoma cancer
- androgenic alopecia
- non-insulin-dependent diabetes mellitus
- posterior polar cataract 31
- periodontitis
- multiple types cataract 31
- dysphagia
- non-melanoma skin cancer
role in cell
- loss
- duplication
- reassembly
- cell death
- organization
- repair
- quantity
- autophagy by
- assembly
- replication in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- detergent resistant lipid raft fraction
- glutaminergic synapse
- constriction sites
- perinuclear region
- cellular membrane
- Nucleus
- Plasma Membrane
- endosomes
- vesicles
- midbody
- cytosol
- cytoplasmic face of plasma membrane
- lysosome membrane
- endosomal membrane
- nuclear pores
- nuclear envelope
- synaptosomes
- autophagic vacuoles
- multivesicular bodies
- kinetochore microtubule
- gap junction plaques
- kinetochores
- postsynaptic density
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Chmp4b gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- membrane fission
- protein transport
- non-lytic virus budding
- nucleus organization
- posttranslational protein targeting to membrane
- protein polymerization
- membrane budding
- non-lytic virus budding from plasma membrane
- regulation of centrosome duplication
- plasma membrane repair
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- cytokinesis after mitosis
- autophagy
- regulation of autophagy
- multivesicular body sorting pathway
- exit from mitosis
- nuclear envelope reassembly
- mitotic metaphase plate congression
- neurological system process
- late endosome to vacuole transport via multivesicular body sorting pathway
- macroautophagy
- vesicle fusion with vacuole
Cellular Component
Where in the cell the gene product is active
- ESCRT III complex
- kinetochore
- multivesicular body
- lysosomal membrane
- autophagic vacuole membrane
- plasma membrane
- internal side of plasma membrane
- nuclear pore
- nuclear envelope
- membrane coat
- nucleus
- endosome
- extracellular vesicular exosome
- cytoplasm
- kinetochore microtubule
- cytosol
- vesicle
- multivesicular body membrane
- midbody
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein homodimerization activity
- protein binding
- cadherin binding