Sycp3 Gene Summary [Mouse]
Predicted to enable DNA binding activity. Involved in female meiosis sister chromatid cohesion; meiotic chromosome segregation; and spermatogenesis. Acts upstream of or within several processes, including cellular response to leukemia inhibitory factor; meiosis I cell cycle process; and sperm DNA condensation. Located in condensed chromosome and germ cell nucleus. Is expressed in several structures, including adrenal gland; alimentary system; brain; genitourinary system; and primordial germ cell. Used to study azoospermia. Human ortholog(s) of this gene implicated in spermatogenic failure 4. Orthologous to human SYCP3 (synaptonemal complex protein 3). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sycp3 |
| Official Name | synaptonemal complex protein 3 [Source:MGI Symbol;Acc:MGI:109542] |
| Ensembl ID | ENSMUSG00000020059 |
| Bio databases IDs | |
| Aliases | synaptonemal complex protein 3 |
| Synonyms | COR1, LOC100362033, RNASCP3, RPRGL4, SCP3, Scp3l, SPGF4, synaptonemal complex protein 3 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sycp3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cor1/Xlr/Xmr conserved region
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- spermatogenic failure 4
- recurrent pregnancy loss 4
- aspermatogenesis
- azoospermia
role in cell
- expression in
- apoptosis
- formation
- activation in
- compaction
- condensation
- attachment
- meiosis
- abnormal morphology
- synapsis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- centromeric region
- chromosome
- interchromatin space
- nucleoplasm
- nuclear envelope
- centromeres
- synaptonemal complexes
- telomeres
- chromosomal arms
- chromosomal axial elements
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sycp3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell division
- meiotic cell cycle
- spermatid development
- male meiosis I
- sperm chromatin condensation
Cellular Component
Where in the cell the gene product is active
- nucleus
- lateral element
- chromosome, centromeric region
- synaptonemal complex
Molecular Function
What the gene product does at the molecular level
- DNA binding
- protein binding