Cisd2 Gene Summary [Mouse]
Predicted to enable 2 iron, 2 sulfur cluster binding activity and protein homodimerization activity. Involved in autophagy of mitochondrion. Located in endoplasmic reticulum membrane and mitochondrial outer membrane. Is expressed in central nervous system and retina. Used to study Wolfram syndrome 2. Human ortholog(s) of this gene implicated in Wolfram syndrome 2. Orthologous to human CISD2 (CDGSH iron sulfur domain 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Cisd2 |
| Official Name | CDGSH iron sulfur domain 2 [Source:MGI Symbol;Acc:MGI:1914256] |
| Ensembl ID | ENSMUSG00000028165 |
| Bio databases IDs | |
| Aliases | CDGSH iron sulfur domain 2 |
| Synonyms | 1500009M05Rik, 1500026J14Rik, 1500031D15Rik, B630006A20Rik, CDGSH iron sulfur domain 2, CDGSH iron sulphur domain 2, ERIS, Miner1, NAF-1, Noxp70, RGD1566242, WFS2, ZCD2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Cisd2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- Iron-containing outer mitochondrial membrane protein N-terminus
- Iron-binding zinc finger CDGSH type
- protein homodimerization
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- growth failure
- blindness
- Wolfram syndrome type 2
- Wolfram syndrome
- premature aging
- neurodegeneration
- exophthalmos
- demyelination
phenotypes
- abnormal behavior
- abnormal eye size
- abnormal glucose homeostasis
- corneal vascularization
- decreased circulating amylase level
- decreased circulating triglyceride level
- hypoactivity
- increased circulating aspartate transaminase level
- increased circulating creatinine level
- increased circulating phosphate level
- increased lean body mass
- abnormal bone mineralization
- abnormal calcium ion homeostasis
- abnormal coat/hair pigmentation
- abnormal defecation
- abnormal mitochondrial crista morphology
- abnormal mitochondrial shape
- abnormal mitochondrion morphology
- abnormal muscle fiber morphology
- abnormal myocardium layer morphology
- abnormal optic nerve morphology
- abnormal respiratory electron transport chain
- abnormal respiratory function
- abnormal sarcomere morphology
- abnormal skeletal muscle fiber morphology
- abnormal skeletal muscle fiber type ratio
- abnormal skeletal muscle morphology
- axon degeneration
- blindness
- corneal opacity
- decreased body mass index
- decreased body size
- decreased body weight
- decreased bone mineral density
- decreased fluid intake
- decreased food intake
- decreased hair follicle number
- decreased heart weight
- decreased insulin secretion
- decreased lean body mass
- decreased oxygen consumption
- decreased subcutaneous adipose tissue amount
- decreased tidal volume
- decreased total body fat amount
- decreased trabecular bone thickness
- demyelination
- dilated sarcoplasmic reticulum
- enhanced autophagy
- exophthalmos
- impaired glucose tolerance
- impaired skeletal muscle contractility
- increased insulin sensitivity
- increased mitochondria size
- kyphosis
- lethargy
- lordosis
- muscle degeneration
- neurodegeneration
- oliguria
- postnatal growth retardation
- premature aging
- premature death
- prominent ears
- retinal neovascularization
- ruffled hair
- small thoracic cavity
- thick epidermis
- tremors
- weakness
role in cell
- binding in
- proliferation
- quantity
- degeneration
- function
- transmembrane potential
- abnormal morphology
- autophagy by
- accumulation in
- glycolysis in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum mitochondria contact site
- perinuclear region
- Endoplasmic Reticulum
- Mitochondria
- reticular perinuclear compartment
- endoplasmic reticulum membrane
- mitochondrial outer membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Cisd2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- autophagy
- regulation of autophagy
- mitochondrion degradation
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- perinuclear endoplasmic reticulum
- membrane
- macromolecular complex
- endoplasmic reticulum
- mitochondrial outer membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA binding
- protein homodimerization activity
- metal ion binding
- 2 iron, 2 sulfur cluster binding