Pclo Gene Summary [Mouse]
Enables profilin binding activity. A structural constituent of presynaptic active zone. Involved in presynaptic actin cytoskeleton organization; protein localization to synapse; and synaptic vesicle clustering. Acts upstream of or within cytoskeleton organization; insulin secretion; and regulation of exocytosis. Located in postsynaptic density. Is expressed in nervous system and sensory organ. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 3. Orthologous to human PCLO (piccolo presynaptic cytomatrix protein). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Pclo |
| Official Name | piccolo (presynaptic cytomatrix protein) [Source:MGI Symbol;Acc:MGI:1349390] |
| Ensembl ID | ENSMUSG00000061601 |
| Bio databases IDs | |
| Aliases | piccolo (presynaptic cytomatrix protein) |
| Synonyms | ACZ, aczonin, CLAM, KIAA0559, LOC108350654, PCH3, Piccolo, piccolo (presynaptic cytomatrix protein), piccolo presynaptic cytomatrix protein, Pico |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Pclo often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Formin Homology Region 1
- cell division protein FtsN
- Kruppel-like factor (KLF) 9, KLF13, KLF14, KLF16, and similar proteins
- Family of unknown function (DUF5585)
- transcription factor binding
- Proline-rich protein
- zDHHC ankyrin repeat binding domain
- Mediator complex subunit 25 synapsin 1
- profilin binding
- FYVE domain like superfamily
- Piccolo Zn-finger
- Cornifin (SPRR) family
- Treacher Collins syndrome protein Treacle
- Domain of unknown function (DUF1720)
- Histone H1-like nucleoprotein HC2
- C2 domain
- Domain present in PSD-95, Dlg, and ZO-1/2
- MAPK-interacting and spindle-stabilising protein-like
- calcium-dependent phospholipid binding
- canonical PDZ domain
- calcium ion binding
- protein binding
- PDZ domain
- Protein of unknown function, DUF612
- zinc finger domain
- structural molecule
- Protein kinase C conserved region 2 (CalB)
- transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- COVID-19
- schizoaffective disorder bipolar subtype
- Graves disease
- depressive disorder
- irritable bowel syndrome
- insomnia
- schizophrenia
- neuroticism
- pontocerebellar hypoplasia, type 3
- bipolar disorder
regulates
- INS
- insulin
- neurotransmitter
role in cell
- organization
- clustering in
- exocytosis by
- clustering
- synaptic depression
- assembly in
- assembly
- abnormal quantity
- recycling
- transport
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- synaptic plasma membrane fractions
- detergent resistant lipid raft fraction
- glutaminergic synapse
- proximal axon
- inner hair cell synaptic ribbon
- cortical cytoskeleton
- cytoskeleton
- perinuclear region
- Golgi Apparatus
- presynaptic membrane
- trans Golgi network
- neuromuscular junctions
- growth cone
- synapse
- rod spherules
- membrane processes
- perikaryon
- axons
- dendrites
- postsynaptic density
- axon terminals
- axospinous synapses
- ribbon synapse
- axosomatic synapses
- axodendritic synapses
- excitatory synapses
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Pclo gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- maintenance of presynaptic active zone structure
- cytoskeleton organization
- insulin secretion
- synaptic vesicle clustering
- protein localization to synapse
- regulation of exocytosis
- synaptic vesicle exocytosis
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- extracellular vesicular exosome
- cytoskeleton
- presynaptic cytoskeletal matrix assembled at active zones
- synapse
- axon
Molecular Function
What the gene product does at the molecular level
- calcium ion binding
- profilin binding
- calcium-dependent phospholipid binding