Dppa2 Gene Summary [Mouse]
Enables chromatin binding activity. Acts upstream of or within several processes, including epigenetic regulation of gene expression; lung-associated mesenchyme development; and positive regulation of stem cell proliferation. Located in nucleus. Is expressed in several structures, including early conceptus; gonad; liver; primordial germ cell; and trunk. Orthologous to human DPPA2 (developmental pluripotency associated 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Dppa2 |
| Official Name | developmental pluripotency associated 2 [Source:MGI Symbol;Acc:MGI:2157523] |
| Ensembl ID | ENSMUSG00000072419 |
| Bio databases IDs | |
| Aliases | developmental pluripotency associated 2 |
| Synonyms | 2410088E07Rik, C80932, CT100, D19Mgi18, developmental pluripotency-associated 2, ECAT15-2, LOC151871, PESCRG1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Dppa2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SAP motif
- Dppa2/4 conserved region in higher vertebrates
- chromatin binding
- protein binding
- Dppa2/4 conserved region
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- premature ovarian failure
role in cell
- expression in
- maintenance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Dppa2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- system development
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- chromatin binding