Rgs14 Gene Summary [Mouse]
Enables GTPase activating protein binding activity and GTPase activator activity. Involved in several processes, including learning or memory; negative regulation of signal transduction; and regulation of synaptic plasticity. Acts upstream of or within mitotic cell cycle. Located in several cellular components, including dendritic spine; microtubule cytoskeleton; and nuclear body. Is active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including cochlea; neural ectoderm; and placenta. Human ortholog(s) of this gene implicated in nephrolithiasis. Orthologous to human RGS14 (regulator of G protein signaling 14). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rgs14 |
| Official Name | regulator of G-protein signaling 14 [Source:MGI Symbol;Acc:MGI:1859709] |
| Ensembl ID | ENSMUSG00000052087 |
| Bio databases IDs | |
| Aliases | regulator of G-protein signaling 14 |
| Synonyms | regulator of G-protein signaling 14, RPIP1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rgs14 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein regulatory motif
- protein kinase binding
- GoLoco motif
- Regulator of G protein signaling (RGS) domain superfamily
- GTPase
- GTPase activator
- enzyme
- protein binding
- Regulator of G protein signaling domain
- microtubule binding
- GDP-dissociation inhibitor
- Raf-like Ras-binding domain
- receptor signaling complex scaffold protein
- Ubl1_cv_Nsp3_N-like
Pathways
Biological processes and signaling networks where the Rgs14 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- gout
- kidney stones
- lichen planus
- inflammatory bowel disease
- ulcerative colitis
- urinary bladder stone
- Huntington disease
- chronic kidney disease
- urolithiasis
- multiple sclerosis
role in cell
- number
- arborization
- organization
- segregation
- cytokinesis
- asymmetric division
- cell division
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- glutaminergic synapse
- spindle apparatus
- Nucleus
- Plasma Membrane
- centrosome
- midbody
- nuclear bodies
- spindle pole
- dendritic spines
- dendrites
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rgs14 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- spindle organization
- negative regulation of MAP kinase activity
- G-protein coupled receptor signaling pathway
- zygote asymmetric cell division
- platelet-derived growth factor receptor signaling pathway
- chromosome segregation
- visual learning
- regulation of G-protein coupled receptor protein signaling pathway
- learning
- mitotic cell cycle
- negative regulation of G-protein coupled receptor protein signaling pathway
- long-term memory
- cell division
- response to oxidative stress
- nucleocytoplasmic transport
- negative regulation of synaptic plasticity
- negative regulation of ERK1 and ERK2 cascade
- long-term synaptic potentiation
- positive regulation of neurogenesis
Cellular Component
Where in the cell the gene product is active
- postsynaptic density
- nuclear body
- PML body
- spindle pole
- plasma membrane
- microtubule
- nucleus
- dendrite
- centrosome
- cytoplasm
- dendritic spine
- spindle
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- GDP-dissociation inhibitor activity
- protein binding
- G-protein alpha-subunit binding
- GTPase activity
- GTPase activator activity
- GTPase activating protein binding
- receptor signaling complex scaffold activity
- microtubule binding